{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:24:06Z","timestamp":1788326646418,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD095494"],"award-info":[{"award-number":["R01HD095494"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD115272"],"award-info":[{"award-number":["R01HD115272"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008036","name":"Faculty of Arts and Sciences, Harvard University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetes is a condition characterized by a loss of pancreatic \u03b2\u2010cell function, which results in the dysregulation of insulin homeostasis. Using a partial pancreatectomy model in axolotl, we aimed to observe the pancreatic response to injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Here we show a comprehensive histological characterization of pancreatic islets in axolotl. Following pancreatic injury, no apparent blastema\u2010like structure was observed. We found a significant, organ\u2010wide increase in cellular proliferation post\u2010resection in the pancreas compared to sham\u2010operated controls. This proliferative response was most robust at the site of injury. Further, an increase in nuclear density was observed, suggesting compensatory congestion as a mechanism of regeneration. We found that \u03b2\u2010cells actively contributed to the increased rates of proliferation upon injury. \u03b2\u2010Cell proliferation manifested in increased \u03b2\u2010cell mass in injured tissue at 2\u2009weeks post\u2010injury. At 4\u2009weeks post\u2010injury, we found organ\u2010wide proliferation to be extinguished while proliferation at the injury site persisted, corresponding to pancreatic tissue recovery. Similarly, total \u03b2\u2010cell mass was comparable to sham after 4\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest a non\u2010blastema\u2010mediated regeneration process takes place in the pancreas, by which pancreatic resection induces whole\u2010organ \u03b2\u2010cell proliferation without the formation of a blastemal structure. This process is analogous to other models of compensatory congestion in axolotl.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dvdy.70060","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T13:10:37Z","timestamp":1752844237000},"page":"748-760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pancreatic injury induces \u03b2\u2010cell regeneration in axolotl"],"prefix":"10.1002","volume":"255","author":[{"given":"Connor J.","family":"Powell","sequence":"first","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology Harvard University  Cambridge Massachusetts USA"},{"name":"Department of Bioengineering Northeastern University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani D.","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology Harvard University  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley R.","family":"Juarez","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology Harvard University  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan T.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology Harvard University  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elane","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology Harvard University  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Payzin\u2010Dogru","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology Harvard University  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Savage","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology Harvard University  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah J.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology Harvard University  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Thornton","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology Harvard University  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Blair","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology Harvard University  Cambridge Massachusetts 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miten","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Northeastern University  Boston Massachusetts USA"},{"name":"Department of Physics Northeastern University  Boston Massachusetts USA"},{"name":"Khoury College of Computer Sciences Northeastern University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3709-6515","authenticated-orcid":false,"given":"Jessica L.","family":"Whited","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology Harvard University  Cambridge Massachusetts USA"},{"name":"The Broad Institute of Harvard and MIT  Cambridge Massachusetts USA"},{"name":"Harvard Stem Cell Institute Harvard University  Cambridge Massachusetts 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