{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:16:14Z","timestamp":1781277374750,"version":"3.54.1"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011747","name":"Novo Nordisk Foundation Center for Basic Metabolic Research","doi-asserted-by":"publisher","award":["NNF21OC0071970"],"award-info":[{"award-number":["NNF21OC0071970"]}],"id":[{"id":"10.13039\/501100011747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006309","name":"Riisfort Fonden","doi-asserted-by":"publisher","award":["RF 8 Oct 2021"],"award-info":[{"award-number":["RF 8 Oct 2021"]}],"id":[{"id":"10.13039\/501100006309","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Diabetes is a group of diseases characterized by loss of \u03b2 cell mass and\/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in \u03b2 cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans (zebrafish). There is a need for new models to study endogenous regeneration pathways. This study proposes the axolotl salamander (\n                      <jats:italic>Ambystoma mexicanum<\/jats:italic>\n                      ) as a model for studying the regeneration of \u03b2 cells and aims to establish a protocol for STZ\u2010induced hyperglycemia to mimic a diabetic state.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this pilot study, five streptozotocin (STZ) protocols were tested, and the most effective one was identified on the basis of glucose tolerance tests. Blood glucose levels were monitored to track both disease progression and remission. Histological examination of the pancreas and systemic effects of STZ treatment were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Induction of a diabetes\u2010like state (hyperglycemia) in axolotls was possible with STZ, but variability among animals suggests the need for a higher degree of normalization or larger sample sizes. Histological regeneration was not observed, though blood glucose levels normalized over time. Some STZ\u2010treated animals developed edema, but its cause remains unknown.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dvdy.70063","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T13:26:51Z","timestamp":1753277211000},"page":"567-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Streptozotocin induced hyperglycemia in the axolotl"],"prefix":"10.1002","volume":"255","author":[{"given":"Pernille Lajer","family":"S\u00f8rensen","sequence":"first","affiliation":[{"name":"Comparative Medicine Lab, Department of Clinical Medicine Aarhus University  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1793-8106","authenticated-orcid":false,"given":"Anita","family":"Dittrich","sequence":"additional","affiliation":[{"name":"Comparative Medicine Lab, Department of Clinical Medicine Aarhus University  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