{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:58:26Z","timestamp":1774447106416,"version":"3.50.1"},"reference-count":282,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Dynamics"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Sox8<\/jats:italic>\n                    ,\n                    <jats:italic>Sox9<\/jats:italic>\n                    , and\n                    <jats:italic>Sox10<\/jats:italic>\n                    arose by multiple rounds of genome duplications from a single\n                    <jats:italic>SoxE<\/jats:italic>\n                    gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders. SoxE proteins play critical roles during the development of multiple tissues in vertebrate embryos, including the neural crest, inner ear, cartilages, and glia cells of diverse origins, heart, gonads, and gastrointestinal tract. Because they recognize the same DNA sequence, possess conserved functional domains, and have overlapping expression profiles, SoxE proteins act partly redundantly in many contexts. However, Sox8, Sox9, and Sox10 also have many unique and tissue\u2010specific functions. In particular, Sox9 plays an essential role in chondrogenesis, whereas Sox10 is a central regulator of pigment and glia cells. The highly context\u2010specific regulation of different sets of target genes by SoxE factors is due to their ability to interact and cooperate with many other proteins including other transcription factors, cofactors, and enzymes, which modulate their regulatory activity. The activity of SoxE proteins is also frequently altered in a context\u2010dependent fashion by post\u2010translational modifications such as phosphorylation, acetylation, and SUMOylation.\n                  <\/jats:p>","DOI":"10.1002\/dvdy.70130","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:11:52Z","timestamp":1774440712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of\n                    <scp>SoxE<\/scp>\n                    transcription factors in development and disease"],"prefix":"10.1002","author":[{"given":"Merin","family":"Lawrence","sequence":"first","affiliation":[{"name":"School of Biological and Chemical Sciences University of Galway, Biomedical Sciences Building  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1300-1331","authenticated-orcid":false,"given":"Gerhard","family":"Schlosser","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Sciences University of Galway, Biomedical Sciences Building  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/346245a0","article-title":"A gene mapping to the sex\u2010determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes","volume":"346","author":"Gubbay J","year":"1990","journal-title":"Nature"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/346240a0","article-title":"A gene from the human sex\u2010determining region encodes a protein with homology to a 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