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During invagination, the OP also generates migratory neuronal populations, including gonadotropin\u2010releasing hormone\u20101 (GnRH\u20101) neurons, somatostatin\u2010expressing neurons, and Prokineticin Receptor 2 (Prokr2) pioneer\/terminal nerve (TN) neurons. Despite extensive research, the genetic lineage and molecular identity of many OP\u2010derived neurons remain unclear. GnRH\u20101 neurons are vital for reproductive functions and chemosensory processing but are genetically distinct from olfactory and vomeronasal sensory neurons. The regulator Goofy\/Gfy is expressed in placode\u2010derived chemosensory neurons. Our study aimed to determine whether its expression is restricted to these neurons or shared among OP derivatives. The 123Cre mouse expresses Cre under the Gfy1 promoter. Cre tracing analyses across embryonic stages showed widespread 123Cre recombination in chemosensory neurons but not in migrating GnRH\u20101. However, at late development and postnatal stages, some Gfy\u2010traced cells appear in the basal forebrain, including a subset of GnRH\u2010positive neurons. These findings demonstrate heterogeneity among migratory nasal neurons and suggest that, besides GnRH\u20101, other nasal\u2010origin neurons also populate the forebrain. Postnatal studies of vomeronasal neurons revealed distinct developmental trajectories for the two main VSN subtypes.<\/jats:p>","DOI":"10.1002\/dvdy.70164","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:17:22Z","timestamp":1781525842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Goofy\/\n                    <scp>123Cre<\/scp>\n                    lineage tracing differentiates olfactory and vomeronasal neurons from\n                    <scp>GnRH<\/scp>\n                    \u20101 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode\u2010derived cells in the brain"],"prefix":"10.1002","author":[{"suffix":"Jr.","given":"Enrico","family":"Amato","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, The Center for Neuroscience Research, The RNA Institute University at Albany, State University of New York  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