{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:02:13Z","timestamp":1784786533240,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE030471"],"award-info":[{"award-number":["R01DE030471"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["604\/21"],"award-info":[{"award-number":["604\/21"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006221","name":"United States - Israel Binational Science Foundation","doi-asserted-by":"publisher","award":["21007"],"award-info":[{"award-number":["21007"]}],"id":[{"id":"10.13039\/100006221","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Dynamics"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The continuously growing mouse incisor serves as a model for stem cell\u2010driven tooth renewal. Although mice possess maxillary and mandibular incisors, most studies have focused on the mandible. Potential differences in structure and renewal between these serially homologous organs remain insufficiently characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mandibular incisors are longer and contain greater enamel volume, mineral density, and mineral content than maxillary incisors, whereas maxillary incisors are more curved and display a larger cross\u2010sectional area. Mineral density increases along the apical\u2010to\u2010incisal axis in both teeth, although mandibular incisors exhibit greater mineral deposition and retention. The maxillary incisor contains a larger pool of cycling progenitors with proliferation dynamics comparable to those of the mandibular incisor. Although ameloblast differentiation initiates at a similar position in both incisors, the mandibular incisor contains a ~20% longer secretory\u2010stage ameloblast region. Consistent with this observation, gene expression analysis reveals earlier\n                      <jats:italic>Igfbpl1<\/jats:italic>\n                      expression onset in the mandible.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Homologous mouse incisors differ in progenitor pool size, ameloblast maturation, and enamel formation. Increased enamel output in the mandible is associated with a prolonged secretory phase, whereas the maxilla contains an expanded progenitor pool. These findings support the maxillary incisor as a complementary model for studying mechanisms that regulate tooth renewal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dvdy.70175","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:15:52Z","timestamp":1784783752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Jaw\u2010specific stem cell dynamics are associated with distinct enamel architecture in mouse incisors"],"prefix":"10.1002","author":[{"given":"Elias","family":"Shahin","sequence":"first","affiliation":[{"name":"The Institute of Biomedical and Oral Research, Faculty of Dental Medicine Hebrew University  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihan","family":"Asmar","sequence":"additional","affiliation":[{"name":"The Institute of Biomedical and Oral Research, Faculty of Dental Medicine Hebrew University  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanako","family":"Takano","sequence":"additional","affiliation":[{"name":"School of Dentistry University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1035-0779","authenticated-orcid":false,"given":"Jimmy K.","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Dentistry University of California Los Angeles  Los Angeles California USA"},{"name":"Molecular Biology Institute University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-5155","authenticated-orcid":false,"given":"Amnon","family":"Sharir","sequence":"additional","affiliation":[{"name":"The Institute of Biomedical and Oral Research, Faculty of Dental Medicine Hebrew University  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13752\u2010021\u201000395\u20106"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091830405"},{"issue":"1","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1083\/jcb.147.1.105","article-title":"Localization of putative stem cells in dental epithelium and their association with notch and Fgf signaling","volume":"147","author":"Harada H","year":"1999","journal-title":"J Cell Biol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fdmed.2022.1068494"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003\u20109969(02)00208\u2010X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.103.Supplement.155"},{"issue":"2","key":"e_1_2_8_8_1","first-page":"325","article-title":"Morphological characteristics of mouse incisor enamel","volume":"189","author":"M\u00f8inichen CB","year":"1996","journal-title":"J Anat"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036299"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781107360150.013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.title.114889"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368\u2010021\u201000677\u20104"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26104905"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmammal\/gyw073"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.12.005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525\u2010142x.2001.01032.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2016"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091870106"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adi0482"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/684607"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10109"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010019\u20100378\u20102"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.05.014"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21778"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050260103"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345740530062401"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.015081"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3791\/51266"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00112"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20109012\u20102_1"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24712"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.03.023"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3791\/66020"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201096630\u20102"},{"issue":"2","key":"e_1_2_8_35_1","first-page":"120","article-title":"Russell and Burch's 3Rs then and now: the need for clarity in definition and purpose","volume":"54","author":"Tannenbaum J","year":"2015","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001420403"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091790403"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345790580024901"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1062359010080078"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118802557.ch3"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/08987564251369073"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596\u2010019\u20100240\u20109"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010019\u20100056\u2010z"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.70175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dvdy.70175","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.70175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:15:54Z","timestamp":1784783754000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.70175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":42,"alternative-id":["10.1002\/dvdy.70175"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.70175","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"value":"1058-8388","type":"print"},{"value":"1097-0177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"assertion":[{"value":"2026-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"dvdy.70175"}}