{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:55:32Z","timestamp":1790855732228,"version":"4.1.0"},"reference-count":112,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001403","name":"Indian Institute of Technology Kanpur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001403","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Dynamics"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neurodevelopmental disorders (NDDs) comprise a spectrum of conditions that impair brain development and nervous system function, resulting in lifelong cognitive, behavioral, and motor disabilities. Globally, more than 3% of children are affected by NDDs. Although advances in next\u2010generation sequencing technology have identified many disease\u2010associated genes, the cellular and molecular mechanisms underlying NDD pathogenesis remain poorly understood. Recent genomic and clinical studies have highlighted the transmembrane (TMEM) family of proteins as emerging contributors to NDDs. TMEM proteins represent a structurally and functionally diverse group that localize to membranes of various cellular organelles, including the endoplasmic reticulum (ER). Several ER\u2010resident TMEM proteins have been increasingly implicated in neurodevelopmental impairments, suggesting a critical role for ER\u2010associated processes in brain development and function. In this review, we describe the key ER\u2010resident TMEM proteins and their association with neurodevelopmental disorders. We discuss the known cellular functions of these proteins, summarize evidence linking their dysfunction to neurodevelopmental phenotypes, and highlight emerging mechanisms by which ER\u2010resident TMEM proteins may contribute to NDD pathogenesis. Finally, we outline key knowledge gaps and discuss how elucidating the functions of these proteins may provide new insights into disease etiology.<\/jats:p>","DOI":"10.1002\/dvdy.70189","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:00:37Z","timestamp":1790852437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The emerging role of\n                    <scp>ER<\/scp>\n                    \u2010localized\n                    <scp>TMEM<\/scp>\n                    proteins in neurodevelopmental disorders"],"prefix":"10.1002","author":[{"given":"Shreni","family":"Priyadarshini","sequence":"first","affiliation":[{"name":"Department of Biological Sciences &amp; Bioengineering Indian Institute of Technology Kanpur  Kanpur Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Kumar","sequence":"additional","affiliation":[{"name":"Integrated Science Education and Research Center Visva\u2010Bharati University  Santiniketan West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-7013","authenticated-orcid":false,"given":"Debdeep","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences &amp; Bioengineering Indian Institute of Technology Kanpur  Kanpur Uttar Pradesh India"},{"name":"Mehta Family Centre for Engineering in Medicine Indian Institute of Technology Kanpur  Kanpur Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000710"},{"key":"e_1_2_10_3_1","volume-title":"Clinical Descriptions 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