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Although studies in mouse provide abundant information about Meis factors function in embryogenesis, little is known about their role in zebrafish.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We generated zebrafish lines carrying null mutations in <jats:italic>meis1a<\/jats:italic>, <jats:italic>meis1b<\/jats:italic>, <jats:italic>meis2a<\/jats:italic>, and <jats:italic>meis2b<\/jats:italic> genes. Only <jats:italic>meis1b<\/jats:italic> mutants are lethal at larval stage around 13\u2009dpf whereas the other mutant lines are viable and fertile. We focused on development of neural crest\u2010derived craniofacial structures such as tendons, cranial nerves, cartilage and accompanying muscles. <jats:italic>Meis1b<\/jats:italic> mutants displayed morphogenetic abnormalities in the cartilage originating from the first and second pharyngeal arches. Meckel's cartilage was shorter and wider with fused anterior symphysis and abnormal chondrocyte organization. This resulted in impaired tendons and muscle fiber connections while tenocyte development was not largely affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Loss\u2010of\u2010function mutation in <jats:italic>meis1b<\/jats:italic> affects cartilage morphology in the lower jaw that leads to disrupted organization of muscles and tendons.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dvdy.731","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T08:39:24Z","timestamp":1722501564000},"page":"40-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transcription factor <scp>Meis1b<\/scp> regulates craniofacial morphogenesis in zebrafish"],"prefix":"10.1002","volume":"254","author":[{"given":"Viktorie","family":"Psutkova","sequence":"first","affiliation":[{"name":"Department of Developmental Biology Institute of Experimental Medicine, Czech Academy of Sciences  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