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In addition to transcription factors, RNA\u2010binding proteins tightly regulate gene expression by controlling the fate of RNA transcripts, thus specific proteins levels within the cell. Rbm24 has been identified as a key player of myogenesis and cardiomyogenesis in several vertebrates, by controlling various aspects of post\u2010transcriptional regulation, including pre\u2010mRNA alternative splicing and mRNA stabilization. In zebrafish, knockdown of\n                      <jats:italic>rbm24a<\/jats:italic>\n                      or\n                      <jats:italic>rbm24b<\/jats:italic>\n                      also causes skeletal and cardiac muscle phenotypes, but how their combined loss affects muscle integrity and function remains elusive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      By genome editing, we have generated\n                      <jats:italic>rbm24a<\/jats:italic>\n                      and\n                      <jats:italic>rbm24b<\/jats:italic>\n                      single mutants as well as double mutants. Structural analyses indicate that homozygous\n                      <jats:italic>rbm24a<\/jats:italic>\n                      and\n                      <jats:italic>rbm24b<\/jats:italic>\n                      double mutants exhibit severe somitic muscle and cardiac phenotypes, although\n                      <jats:italic>rbm24b<\/jats:italic>\n                      single mutants are obviously normal. We further show that the loss of\n                      <jats:italic>rbm24a<\/jats:italic>\n                      and\n                      <jats:italic>rbm24b<\/jats:italic>\n                      disrupts sarcomere organization, impairing functional contractility and motility of skeletal and cardiac muscles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>rbm24<\/jats:italic>\n                      mutant zebrafish represents a new genetic tool for in\u2010depth studies of Rbm24\u2010mediated post\u2010transcriptional regulation of skeletal and cardiac muscle development, disease and regeneration.\n                    <\/jats:p>\n                  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