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Most of the neonates affected by mandibular abnormalities have a sequence of secondary anomalies, including airway obstruction and feeding problems, that reduce the quality of life. In the event of lacking corrective surgeries, patients with mandibular congenital disorders suffer from additional lifelong problems such as sleep apnea and temporomandibular disorders, among others. The goal of this systematic review is to gather evidence on hormonal and genetic factors that are involved in signaling pathways and interactions that are potentially associated with the nonsyndromic mandibular disorders. We found that members of FGF and BMP pathways, including FGF8\/10, FGFR2\/3, BMP2\/4\/7, BMPR1A, ACVR1, and ACVR2A\/B, have a prominent number of gene\u2010gene interactions among all identified genes in this review. Gene ontology of the 154 genes showed that the functional gene sets are involved in all aspects of cellular processes and organogenesis. Some of the genes identified by the genome\u2010wide association studies of common mandibular disorders are involved in skeletal formation and growth retardation based on animal models, suggesting a potential direct role as genetic risk factors in the common complex jaw disorders. <jats:italic>Developmental Dynamics<\/jats:italic> 248:162\u2010172, 2019. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.8","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T17:08:59Z","timestamp":1545412139000},"page":"162-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Systematic review of hormonal and genetic factors involved in the nonsyndromic disorders of the lower jaw"],"prefix":"10.1002","volume":"248","author":[{"given":"Srishti","family":"Manocha","sequence":"first","affiliation":[{"name":"Center for Craniofacial Research, Department of Diagnostic and Biomedical 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