{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:18:31Z","timestamp":1790813911522,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Subfamily II of the solute\u2010linked carrier 39A superfamily contains three well\u2010conserved zinc transporters (ZIPs1, 2, 3) whose physiological functions are unknown. We generated mice homozygous for knockout alleles of <jats:italic>ZIP1<\/jats:italic> and both <jats:italic>ZIP1<\/jats:italic> and <jats:italic>ZIP 3<\/jats:italic> (double\u2010knockout). These mice were apparently normal when dietary zinc was replete, but when dietary zinc was limited during pregnancy embryos from <jats:italic>ZIP1<\/jats:italic> or <jats:italic>ZIP3<\/jats:italic> knockout mice were two to three times more likely to develop abnormally than those in wildtype mice, and 91% (71\/78) of embryos developed abnormally in <jats:italic>ZIP1, ZIP3<\/jats:italic> double\u2010knockout mice. Analysis of the patterns of expression of these genes in mice revealed predominate expression in intestinal stromal cells, nephric\u2010tubular epithelial cells, pancreatic ductal epithelial cells, and hepatocytes surrounding the central vein. This suggests that these zinc transporters function, at least in part, in the redistribution and\/or retention of zinc rather than its acquisition from the diet. In conclusion, mutations in the <jats:italic>ZIP1<\/jats:italic> and <jats:italic>ZIP3<\/jats:italic> zinc transporter genes are silent when dietary intake of zinc is normal, but can dramatically compromise the success of pregnancy when dietary intake of zinc is limiting. genesis 44:239\u2013251, 2006. Published 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvg.20211","type":"journal-article","created":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T20:52:07Z","timestamp":1146516727000},"page":"239-251","source":"Crossref","is-referenced-by-count":105,"title":["Mouse <i>ZIP1<\/i> and <i>ZIP3<\/i> genes together are essential for adaptation to dietary zinc deficiency during pregnancy"],"prefix":"10.1002","volume":"44","author":[{"given":"Jodi","family":"Dufner\u2010Beattie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin L.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Geiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen 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