{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:54:55Z","timestamp":1791996895523,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,9,14]],"date-time":"2007-09-14T00:00:00Z","timestamp":1189728000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>TEAD2, one of the first transcription factors expressed at the beginning of mammalian development, appears to be required during neural development. For example, <jats:italic>Tead2<\/jats:italic> expression is greatest in the dorsal neural crest where it appears to regulate expression of <jats:italic>Pax3<\/jats:italic>, a gene essential for brain development. Consistent with this hypothesis, we found that inactivation of the <jats:italic>Tead2<\/jats:italic> gene in mice significantly increased the risk of exencephaly (a defect in neural tube closure). However, none of the embryos exhibited spina bifida, the major phenotype of <jats:italic>Pax3<\/jats:italic> nullizygous embryos, and expression of <jats:italic>Pax3<\/jats:italic> in E11.5 <jats:italic>Tead2<\/jats:italic> nullizygous embryos was normal. Thus, <jats:italic>Tead2<\/jats:italic> plays a role in neural tube closure that is independent of its putative role in <jats:italic>Pax3<\/jats:italic> regulation. In addition, the risk of exencephaly was greatest with <jats:italic>Tead2<\/jats:italic> nullizygous females, and could be suppressed either by folic acid or pifithrin\u2010\u03b1. These results reveal a maternal genetic contribution to neural tube closure, and suggest that <jats:italic>Tead2<\/jats:italic>\u2010deficient mice provide a model for anencephaly, a common human birth defect that can be prevented by folic acid. genesis 45:577\u2013587, 2007. Published 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvg.20330","type":"journal-article","created":{"date-parts":[[2007,9,14]],"date-time":"2007-09-14T22:17:39Z","timestamp":1189808259000},"page":"577-587","source":"Crossref","is-referenced-by-count":97,"title":["Transcription factor TEAD2 is involved in neural tube closure"],"prefix":"10.1002","volume":"45","author":[{"given":"Kotaro J.","family":"Kaneko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Kohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin 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