{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:46:12Z","timestamp":1788468372717,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,9,14]],"date-time":"2007-09-14T00:00:00Z","timestamp":1189728000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Twist1<\/jats:italic> is the mouse ortholog of <jats:italic>TWIST1<\/jats:italic>, the human gene mutated in Saethre\u2010Chotzen syndrome. Previously, a <jats:italic>Twist1<\/jats:italic> null allele was generated by gene targeting in mouse embryonic stem cells. <jats:italic>Twist1<\/jats:italic> heterozygous mice develop polydactyly and a craniofacial phenotype similar to Saethre\u2010Chotzen patients. Mice homozygous for the <jats:italic>Twist1<\/jats:italic> null allele die around embryonic day 11.5 (E11.5) with cranial neural tube closure and vascular defects, hindering <jats:italic>in vivo<\/jats:italic> studies of <jats:italic>Twist1<\/jats:italic> function at later stages of development. Here, we report the generation of a <jats:italic>Twist1<\/jats:italic> conditional null allele in mice that functions like a wild\u2010type allele but can be converted to a null allele upon Cre\u2010mediated recombination. genesis 45:588\u2013592, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvg.20332","type":"journal-article","created":{"date-parts":[[2007,9,14]],"date-time":"2007-09-14T19:46:24Z","timestamp":1189799184000},"page":"588-592","source":"Crossref","is-referenced-by-count":48,"title":["Generation of a <i>Twist1<\/i> conditional null allele in the mouse"],"prefix":"10.1002","volume":"45","author":[{"given":"You\u2010Tzung","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter O.","family":"Akinwunmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Min","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver H.","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Behringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90522-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81527-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(04)00058-9"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-003-2284-x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.6.945"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2001.6523"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1526-968X(200005)27:1<12::AID-GENE30>3.0.CO;2-X"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.6.686"},{"key":"e_1_2_1_10_1","first-page":"97","article-title":"Eine eigenartige familiare entwicklungsstorung (akrocephalosyndaktylie, dysostosis, craniofacialis und hypertelorismus)","volume":"55","author":"Chotzen F","year":"1932","journal-title":"MonatschrKinderheilkdSS"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20717"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-42"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1525"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002040309"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80553-X"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.11.6563"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-36"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10068"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1995.0023"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/336348a0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90385-R"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<99::AID-GENE1>3.0.CO;2-B"},{"key":"e_1_2_1_23_1","volume-title":"Manipulating the mouse embryo: A laboratory manual","author":"Nagy A","year":"2003"},{"key":"e_1_2_1_24_1","volume-title":"Mouse phenotype. 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