{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:22:40Z","timestamp":1790936560925,"version":"4.1.0"},"reference-count":71,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,11,6]],"date-time":"2007-11-06T00:00:00Z","timestamp":1194307200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The small heat shock protein <jats:italic>Hsp27<\/jats:italic> has been shown to be involved in a diverse array of cellular processes, including cellular stress response, protein chaperone activity, regulation of cellular glutathione levels, apoptotic signaling, and regulation of actin polymerization and stability. Furthermore, mutation within <jats:italic>Hsp27<\/jats:italic> has been associated with the human congenital neuropathy Charcot\u2010Marie Tooth (CMT) disease. <jats:italic>Hsp27<\/jats:italic> is known to be expressed in developing embryonic tissues; however, little has been done to determine the endogenous requirement for <jats:italic>Hsp27<\/jats:italic> in developing embryos. In this study, we show that depletion of XHSP27 protein results in a failure of cardiac progenitor fusion resulting in cardia bifida. Furthermore, we demonstrate a concomitant disorganization of actin filament organization and defects in myofibril assembly. Moreover, these defects are not associated with alterations in specification or differentiation. We have thus demonstrated a critical requirement for XHSP27 in developing cardiac and skeletal muscle tissues. genesis 45:667\u2013678, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvg.20340","type":"journal-article","created":{"date-parts":[[2007,11,6]],"date-time":"2007-11-06T21:16:27Z","timestamp":1194383787000},"page":"667-678","source":"Crossref","is-referenced-by-count":51,"title":["Small heat shock protein Hsp27 is required for proper heart tube formation"],"prefix":"10.1002","volume":"45","author":[{"given":"Daniel D.","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen S.","family":"Christine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Showell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank L.","family":"Conlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9441"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/152165401317291156"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(200004)183:1<100::AID-JCP12>3.0.CO;2-F"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.23.2993"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)32060-4"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0604-547"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-008X(03)00226-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/s00427-002-0276-6","article-title":"Developmental expression of the Xenopus laevis Tbx20 orthologue","volume":"212","author":"Brown DD","year":"2003","journal-title":"Dev Genes Evol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modgep.2006.03.003"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01596"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/35023595"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000252323.83137.fe"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(98)00243-3"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00749-3"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:15:2:109"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(63)80016-6"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.07.024"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1354"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010856200"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2006.00484.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.8.3073"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119.4.1079"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.1020140204"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.23.3003"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.16.4584"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02420"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(08)60307-6"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000148825.99184.50"},{"key":"e_1_2_1_30_1","first-page":"273","article-title":"HSP27 phosphorylation\u2010mediated resistance against actin fragmentation and cell death induced by oxidative stress","volume":"56","author":"Huot J","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53882-5"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0071"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.10.1279"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1998.0646"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9558"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.6.1385"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.8.1048"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/35018092"},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","unstructured":"LangdonYG GoetzSC BergAE SwanikJT ConlonFL.2007.SHP\u20102 is required for the Maintenance of Cardiac Progenitors. 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