{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:38:39Z","timestamp":1762954719262},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,11,6]],"date-time":"2007-11-06T00:00:00Z","timestamp":1194307200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mitogen\u2010inducible gene 6 (<jats:italic>Mig\u20106<\/jats:italic>) is a stress\u2010induced gene that serves as a negative regulator of epidermal growth factor (EGF) signaling and acts as a tumor suppressor. Ablation of <jats:italic>Mig\u20106<\/jats:italic> results in a significant percentage of embryo lethality as well as abnormalities in multiple tissues. To understand the physiological roles of <jats:italic>Mig\u20106<\/jats:italic>, a conditional null allele, <jats:italic>Mig\u20106<\/jats:italic><jats:sup><jats:italic>f\/f<\/jats:italic><\/jats:sup> was generated by introducing LoxP sites that flank exons 2 and 4. The <jats:italic>Mig\u20106<\/jats:italic><jats:sup><jats:italic>f\/f<\/jats:italic><\/jats:sup> allele was validated by generating recombined <jats:italic>Mig\u20106<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice using the Zp3\u2010Cre system. The conditional null allele was confirmed by assaying for <jats:italic>Mig\u20106<\/jats:italic> gene expression in liver, lung, uterus, and skin. The recombined <jats:italic>Mig\u20106<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice developed pathological changes, such as degenerative joint diseases and skin hyperplasia similar to the previously reported <jats:italic>Mig\u20106<\/jats:italic> germline null allele. In addition, these mice also had enlarged uteri with endometrial hyperplasia. In summary, this <jats:italic>Mig\u20106<\/jats:italic><jats:sup><jats:italic>f\/f<\/jats:italic><\/jats:sup> mouse is a useful tool for the functional study of the <jats:italic>Mig\u20106<\/jats:italic> gene in a tissue\u2010specific fashion. genesis 45:716\u2013721, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvg.20348","type":"journal-article","created":{"date-parts":[[2007,11,6]],"date-time":"2007-11-06T22:18:03Z","timestamp":1194387483000},"page":"716-721","source":"Crossref","is-referenced-by-count":37,"title":["Generation of a <i>Mig\u20106<\/i> conditional null allele"],"prefix":"10.1002","volume":"45","author":[{"given":"Nili","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell 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