{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:18:45Z","timestamp":1778660325933,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T00:00:00Z","timestamp":1239148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>BMPRIA and its high\u2010affinity ligand BMP4 have recently been shown to be expressed in the \u03b2\u2010cells of the pancreas. Here, we report the abnormalities of heterozygous mice for <jats:italic>Bmpr1a<\/jats:italic> in glucose metabolism during the course of intraperitoneal glucose tolerance test. The heterozygous mice had increased blood glucose levels throughout the first 2.5 h after the administration of glucose. Analysis of glucose\u2010stimulated insulin secretion (GSIS) indicates that insulin secretion in the heterozygous mice is compromised, and induction of secreted insulin by stimulation is substantially lower compared with the wild\u2010type controls. No apparent abnormalities in pancreas, thyroid, and liver were seen upon histological examination. Real\u2010time PCR results of selected genes showed an increase in the mRNA level of <jats:italic>Ins1<\/jats:italic> and <jats:italic>Ins2<\/jats:italic> in the heterozygous group. These results indicate that the glucose\u2010sensing pathway in these heterozygous mice is altered because of the heterozygosity in <jats:italic>Bmpr1a<\/jats:italic>. Together, our data suggest that BMP signaling through BMPRIA plays an important role in glucose metabolism and possibly working through the GSIS pathway. genesis 47:385\u2013391, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvg.20513","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T14:22:06Z","timestamp":1239200526000},"page":"385-391","source":"Crossref","is-referenced-by-count":23,"title":["Abnormal glucose metabolism in heterozygous mutant mice for a type I receptor required for BMP signaling"],"prefix":"10.1002","volume":"47","author":[{"given":"Gregory J.","family":"Scott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manas 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