{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:32:18Z","timestamp":1790861538583,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,5,4]],"date-time":"2009-05-04T00:00:00Z","timestamp":1241395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Tbx18<\/jats:italic> is a T\u2010Box transcription factor that has specific expression and indispensible function in the lower urinary tract. Here, we report the generation and characterization of a bacterial artificial chromosome (BAC) transgene expressing Cre under the control of <jats:italic>Tbx18<\/jats:italic> regulatory elements. When crossed to the <jats:italic>ROSA26R\u2010lacZ<\/jats:italic> reporter mice, the <jats:italic>Tbx18\u2010Cre<\/jats:italic> transgene mediates <jats:italic>loxP<\/jats:italic> recombination in the mesenchymal derivatives in the lower urinary tract, especially in the smooth muscle cells (SMCs) and the stromal cells. There is no expression of this transgene in the urothelium or in the kidney. This <jats:italic>Tbx18\u2010Cre<\/jats:italic> transgene recapitulates the endogenous <jats:italic>Tbx18<\/jats:italic> expression in the urinary system and can be used for the study of the development, physiology, and diseases in the urinary tract. Its additional expression in the epicardium, limb, vibrissae, and other structures would be useful for studies in the relevant fields. genesis 47:409\u2013413, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvg.20515","type":"journal-article","created":{"date-parts":[[2009,5,4]],"date-time":"2009-05-04T13:41:26Z","timestamp":1241444486000},"page":"409-413","source":"Crossref","is-referenced-by-count":29,"title":["Cre\/lox recombination in the lower urinary tract"],"prefix":"10.1002","volume":"47","author":[{"given":"Yinqiu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyush","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiusha","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Coussens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,5,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26027"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.004234"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06969"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.1078"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20049"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.22.010305.104340"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00009.2004"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00427-004-0415-3"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31250"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01858"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609326103"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602087103"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2205"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/5007"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.011270"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106483"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.22.5301"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/2417"}],"container-title":["genesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvg.20515","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvg.20515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T02:39:41Z","timestamp":1699929581000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dvg.20515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,4]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1002\/dvg.20515"],"URL":"https:\/\/doi.org\/10.1002\/dvg.20515","archive":["Portico"],"relation":{},"ISSN":["1526-954X","1526-968X"],"issn-type":[{"value":"1526-954X","type":"print"},{"value":"1526-968X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,4]]}}}