{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:22:07Z","timestamp":1792797727793,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,5,4]],"date-time":"2009-05-04T00:00:00Z","timestamp":1241395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transforming growth factor \u03b21 (TGF\u03b21) is a multifunctional growth factor involved in wound healing, tissue fibrosis, and in the pathogenesis of many syndromic diseases (e.g., Marfan syndrome, Camurati\u2010Engelmann disease) and muscular, neurological, ophthalmic, cardiovascular and immunological disorders, and cancer. Since the generation of <jats:italic>Tgfb1<\/jats:italic> knockout mice, there has been extraordinary progress in understanding its physiological and pathophysiological function. Here, we report the generation of a conditional knockout allele for <jats:italic>Tgfb1<\/jats:italic> in which its exon 6 is flanked with <jats:italic>LoxP<\/jats:italic> sites. As proof of principle, we crossed these mice to <jats:italic>LckCre<\/jats:italic> transgenic mice and specifically disrupted <jats:italic>Tgfb1<\/jats:italic> in T cells. The results indicate that T\u2010cell\u2010produced TGF\u03b21 is required for normal in vivo regulation of peripheral T\u2010cell activation, maintenance of T\u2010cell homeostasis, and suppression of autoimmunity. genesis 47:423\u2013431, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvg.20516","type":"journal-article","created":{"date-parts":[[2009,5,4]],"date-time":"2009-05-04T13:41:42Z","timestamp":1241444502000},"page":"423-431","source":"Crossref","is-referenced-by-count":52,"title":["Generation of mice with a conditional allele for transforming growth factor beta 1 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