{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:20:27Z","timestamp":1790882427031,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T00:00:00Z","timestamp":1255478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tissue\u2010specific transgene expression in the prostate epithelium has previously been achieved using short prostate\u2010specific promoters, rendering transgenic mouse lines susceptible to integration site\u2010dependent effects. Here we demonstrate the applicability of bacterial artificial chromosome (BAC) technology to transgene expression in the prostate epithelium. We present mouse lines expressing an inducible Cre protein (MerCreMer) under the control of regulatory elements of the probasin gene on a BAC. These mouse lines show high organ specificity, high transgene expression in anterior, dorsal and lateral prostate lobes, no background Cre recombination using a reporter strain and adjustable amounts of Cre\u2010induced recombination upon tamoxifen induction. Together with two recently reported transgenic lines expressing the Cre\u2010ERT2 protein from small prostate\u2010specific promoters, these mouse lines will be useful in research focused on prostate\u2010specific disorders such as benign hyperplasia or cancer. genesis 47:757\u2013764, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvg.20558","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T16:27:17Z","timestamp":1255537637000},"page":"757-764","source":"Crossref","is-referenced-by-count":15,"title":["A Probasin\u2010MerCreMer BAC allows inducible recombination in the mouse prostate"],"prefix":"10.1002","volume":"47","author":[{"given":"Andreas","family":"Birbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399408000689"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.1078"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.11.9.9974"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008918913249"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.8.2.230"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01338-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1998.2307"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20386"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1159"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)32368-6"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1526-968X(200011\/12)28:3\/4<147::AID-GENE90>3.0.CO;2-G"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.97.1.39"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712021105"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199611)180:3<295::AID-PATH663>3.0.CO;2-W"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-0946"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh1301.092687"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012025199"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.33164"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.1999.184"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(00)00551-7"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0997-859"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.12.7837"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/2417"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/24.4.543"}],"container-title":["genesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvg.20558","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvg.20558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T16:04:29Z","timestamp":1699891469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dvg.20558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,14]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1002\/dvg.20558"],"URL":"https:\/\/doi.org\/10.1002\/dvg.20558","archive":["Portico"],"relation":{},"ISSN":["1526-954X","1526-968X"],"issn-type":[{"value":"1526-954X","type":"print"},{"value":"1526-968X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,14]]}}}