{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:07:31Z","timestamp":1791209251192,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T00:00:00Z","timestamp":1264377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Notch signaling is essential for embryonic vascular development in mammals and other vertebrates. Here we show that mouse embryos with conditional activation of the <jats:italic>Notch1<\/jats:italic> gene in endothelial cells (<jats:italic>Notch1<\/jats:italic> gain of function embryos) exhibit defects in vascular remodeling increased diameter of the dorsal aortae, and form arteriovenous malformations. Conversely, embryos with either constitutive or endothelial cell\u2010specific <jats:italic>Notch1<\/jats:italic> gene deletion also have vascular defects, but exhibit decreased diameter of the dorsal aortae and form arteriovenous malformations distinctly different from the <jats:italic>Notch1<\/jats:italic> gain of function mutants. Surprisingly, embryos homozygous for mutations of the ephrinB\/EphB pathway genes <jats:italic>Efnb2<\/jats:italic> and <jats:italic>Ephb4<\/jats:italic> exhibit vascular defects and arteriovenous malformations that phenocopy the <jats:italic>Notch1<\/jats:italic> gain of function mutants. These results suggest that formation of arteriovenous malformations in <jats:italic>Notch1<\/jats:italic> gain of function mutants and ephrinB\/EphB pathway loss of function mutant embryos occurs by different mechanisms. genesis 48:146\u2013150, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvg.20599","type":"journal-article","created":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T16:23:44Z","timestamp":1264436624000},"page":"146-150","source":"Crossref","is-referenced-by-count":92,"title":["<i>Notch1<\/i> activation in mice causes arteriovenous malformations phenocopied by ephrinB2 and EphB4 mutants"],"prefix":"10.1002","volume":"48","author":[{"given":"Luke T.","family":"Krebs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Starling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander V.","family":"Chervonsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gridley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,25]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-8-117"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2009"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1239004"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1134042"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407290101"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80342-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.12.011"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.004184"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4226"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000266408.42939.e4"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.01.020"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.022475"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.6.741"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1239204"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.11.1343"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9209"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.193185"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(91)90434-D"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.01.015"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1589207"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.6.707"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-112748"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091584598"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81436-1"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-170381"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.01.014"}],"container-title":["genesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvg.20599","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvg.20599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T05:47:45Z","timestamp":1700545665000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dvg.20599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,25]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1002\/dvg.20599"],"URL":"https:\/\/doi.org\/10.1002\/dvg.20599","archive":["Portico"],"relation":{},"ISSN":["1526-954X","1526-968X"],"issn-type":[{"value":"1526-954X","type":"print"},{"value":"1526-968X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,25]]}}}