{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:24:30Z","timestamp":1778585070232,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,2,22]],"date-time":"2010-02-22T00:00:00Z","timestamp":1266796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Brain\u2010derived neurotrophic factor (BDNF), a member of the neurotrophin family of neurotrophic factors, has important functions in the peripheral and central nervous system of vertebrates. We have generated bacterial artificial chromosome (BAC) transgenic mice harboring 207 kb of the rat <jats:italic>BDNF<\/jats:italic> (<jats:italic>rBDNF<\/jats:italic>) locus containing the gene, 13 kb of genomic sequences upstream of <jats:italic>BDNF<\/jats:italic> exon I, and 144 kb downstream of protein encoding exon IX, in which protein coding region was replaced with the <jats:italic>lacZ<\/jats:italic> reporter gene. This <jats:italic>BDNF\u2010<\/jats:italic>BAC drove transgene expression in the brain, heart, and lung, recapitulating endogenous <jats:italic>BDNF<\/jats:italic> expression to a larger extent than shorter rat <jats:italic>BDNF<\/jats:italic> transgenes employed previously. Moreover, kainic acid induced the expression of the transgenic <jats:italic>BDNF<\/jats:italic> mRNA in the cerebral cortex and hippocampus through preferential activation of promoters I and IV, thus recapitulating neuronal activity\u2010dependent transcription of the endogenous <jats:italic>BDNF<\/jats:italic> gene. genesis 48:214\u2013219, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvg.20606","type":"journal-article","created":{"date-parts":[[2010,2,22]],"date-time":"2010-02-22T17:01:45Z","timestamp":1266858105000},"page":"214-219","source":"Crossref","is-referenced-by-count":13,"title":["BAC transgenic mice reveal distal cis\u2010regulatory elements governing BDNF gene 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