{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:31:46Z","timestamp":1783179106681,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,8,22]],"date-time":"2011-08-22T00:00:00Z","timestamp":1313971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The p75<jats:sup>NTR<\/jats:sup> neurotrophin receptor has been implicated in multiple biological and pathological processes. While significant advances have recently been made in understanding the physiologic role of p75<jats:sup>NTR<\/jats:sup>, many details and aspects remain to be determined. This is in part because the two existing knockout mouse models (Exons 3 or 4 deleted, respectively), both display features that defy definitive conclusions. Here we describe the generation of mice that carry a conditional p75<jats:sup>NTR<\/jats:sup> (p75<jats:sup>NTR\u2010FX<\/jats:sup>) allele made by flanking Exons 4\u20136, which encode the transmembrane and all cytoplasmic domains, by loxP sites. To validate this novel conditional allele, both neural crest\u2010specific p75<jats:sup>NTR<\/jats:sup>\/Wnt1\u2010Cre mutants and conventional p75<jats:sup>NTR<\/jats:sup> null mutants were generated. Both mutants displayed abnormal hind limb reflexes, implying that loss of p75<jats:sup>NTR<\/jats:sup> in neural crest\u2010derived cells causes a peripheral neuropathy similar to that seen in conventional p75<jats:sup>NTR<\/jats:sup> mutants. This novel conditional p75<jats:sup>NTR<\/jats:sup> allele will offer new opportunities to investigate the role of p75<jats:sup>NTR<\/jats:sup> in specific tissues and cells. genesis 49:862\u2013869, 2011. \u00a9 2011 Wiley\u2010Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvg.20747","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T18:34:31Z","timestamp":1300300471000},"page":"862-869","source":"Crossref","is-referenced-by-count":43,"title":["Generation of mice with a conditional allele for the p75<sup>NTR<\/sup> neurotrophin receptor gene"],"prefix":"10.1002","volume":"49","author":[{"given":"Emil","family":"Bogenmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny S.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang\u2010Tung","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Pierchala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesa","family":"Kaartinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.04.001"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04781.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.8.1671"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2003.12.003"},{"key":"e_1_2_4_6_1","volume-title":"Antibodies. A laboratory manual","author":"Harlow E","year":"1988"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.21.e92"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.8.1607"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-415"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8128229"},{"key":"e_1_2_4_11_1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1242\/dev.120.4.1027","article-title":"p75\u2010deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF","volume":"120","author":"Lee KF","year":"1994","journal-title":"Development"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90286-L"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.07.032"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5397-03.2004"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302376200"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00016-3"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20533"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.06.010"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn730"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.1025"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.09.034"}],"container-title":["genesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvg.20747","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvg.20747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T14:34:27Z","timestamp":1700490867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dvg.20747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,22]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1002\/dvg.20747"],"URL":"https:\/\/doi.org\/10.1002\/dvg.20747","archive":["Portico"],"relation":{},"ISSN":["1526-954X","1526-968X"],"issn-type":[{"value":"1526-954X","type":"print"},{"value":"1526-968X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,22]]}}}