{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T19:56:51Z","timestamp":1778961411736,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T00:00:00Z","timestamp":1361750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Postmortem studies have revealed a downregulation of the transcription factor <jats:italic>Pax5<\/jats:italic> in GABAergic neurons in bipolar disorder, a neurodevelopmental disorder, raising the question whether <jats:italic>Pax5<\/jats:italic> in GABAergic neurons has a role in normal brain development. In a genetic approach to study functions of <jats:italic>Pax5<\/jats:italic> in GABAergic neurons, <jats:italic>Pax5<\/jats:italic> was specifically deleted in GABAergic neurons from <jats:italic>Pax5<\/jats:italic> floxed mice using a novel <jats:italic>Gad1\u2010Cre<\/jats:italic> transgenic mouse line expressing Cre recombinase in <jats:italic>Gad1<\/jats:italic>\u2010positive, that is, GABAergic neurons. Surprisingly, these mice developed a marked enlargement of the lateral ventricles at approximately 7 weeks of age, which was lethal within 1\u20132 weeks of its appearance. This hydrocephalus phenotype was observed in mice homozygous or heterozygous for the <jats:italic>Pax5<\/jats:italic> conditional knockout, with a gene dosage\u2010dependent penetrance. By QTL (quantitative trait loci) mapping, a 3.5 Mb segment on mouse chromosome 4 flanked by markers <jats:italic>D4Mit237<\/jats:italic> and <jats:italic>D4Mit214<\/jats:italic> containing approximately 92 genes including <jats:italic>Pax5<\/jats:italic> has previously been linked to differences in lateral ventricular size. Our findings are consistent with <jats:italic>Pax5<\/jats:italic> being a relevant gene underlying this QTL phenotype and demonstrate that <jats:italic>Pax5<\/jats:italic> in GABAergic neurons is essential for normal ventricular development. genesis 51:234\u2013245. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvg.22370","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T17:36:25Z","timestamp":1359048985000},"page":"234-245","source":"Crossref","is-referenced-by-count":18,"title":["GABAergic neurons regulate lateral ventricular development via transcription factor <i>Pax5<\/i>"],"prefix":"10.1002","volume":"51","author":[{"given":"Nobuhisa","family":"Ohtsuka","sequence":"first","affiliation":[{"name":"Program in Structural and Molecular Neuroscience McLean Hospital Belmont Massachusetts"},{"name":"Department of Psychiatry Harvard Medical School Boston 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