{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:47:16Z","timestamp":1791150436178,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T00:00:00Z","timestamp":1386201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A loss of function of SIP1 (Smad interacting protein 1) in the mouse as well as in human of Mowat\u2013Wilson syndrome results in severe and multiple defects in neural tissue development, especially in the brain. However, no detailed expression analysis of SIP1 during brain development has been previously reported. In this study, we describe the generation of an EGFP knock\u2010in reporter mouse for the <jats:italic>Sip1<\/jats:italic> locus and our subsequent analysis of SIP1\u2010EGFP fusion protein expression during brain development. SIP1\u2010EGFP expression was observed in the pyramidal neurons of the hippocampus, the dentate gyrus, and the postmitotic neurons in the cerebral cortex. In layer 5 of the cerebral cortex, SIP1\u2010EGFP expression was complementary to the Ctip2\u2010expressing neurons, most of which are thought to be the cortico\u2010spinal neurons. This suggested that SIP1\u2010EGFP expressing cells might have the specific trajectory targets other than the spinal region. We further observed SIP1\u2010EGFP expression in oligodendrocytes of the corpus callosum and fimbria, Bergmann glial cells of the cerebellum, the olfactory bulb, and in the serotonergic and dopaminergic neurons of the raphe nuclei in the brainstem. These findings may help to clarify the unknown roles of SIP1 in these cells and the pathoetiology of Mowat\u2010Wilson syndrome. genesis 52:56\u201367, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvg.22726","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T02:21:55Z","timestamp":1384741315000},"page":"56-67","source":"Crossref","is-referenced-by-count":19,"title":["SIP1 expression patterns in brain investigated by generating a SIP1\u2010EGFP reporter knock\u2010in mouse"],"prefix":"10.1002","volume":"52","author":[{"given":"Yuriko","family":"Nishizaki","sequence":"first","affiliation":[{"name":"Department of Perinatology Institute for Developmental Research, Aichi Human Service Center Kasugai Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Perinatology Institute for Developmental Research, Aichi Human 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