{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:52:18Z","timestamp":1791193938754,"version":"4.1.0"},"reference-count":84,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T00:00:00Z","timestamp":1401753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R21HL097113-01"],"award-info":[{"award-number":["R21HL097113-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Congenital heart disease (CHD) is the most common birth defect. However, the majority of CHD cases have unknown etiology. Here we report the identification of ASXL2 and ASXL1, two homologous chromatin factors, as novel regulators of heart development. <jats:italic>Asxl2<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> fetuses have reduced body weight and display congenital heart malformations including thickened compact myocardium in the left ventricle, membranous ventricular septal defect, and atrioventricular valval stenosis. Although most <jats:italic>Asxl2<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> animals survive to term, the neonates have patent ductus arteriosus and consequent lung hemorrhage and die soon after birth. <jats:italic>Asxl1<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> fetuses have reduced body weight and display cleft palate, anophthalmia as well as ventricular septal defects and a failure in lung maturation. From these results, we conclude that normal heart development requires both ASXL proteins. In particular, ASXL2 plays an important role in heart morphogenesis and the transition from fetal to postnatal circulation. genesis 52:671\u2013686, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvg.22793","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T18:54:30Z","timestamp":1400871270000},"page":"671-686","source":"Crossref","is-referenced-by-count":16,"title":["<i>Additional sex combs\u2010like<\/i> family genes are required for normal cardiovascular development"],"prefix":"10.1002","volume":"52","author":[{"given":"Andrea L.","family":"McGinley","sequence":"first","affiliation":[{"name":"Department of Biological Sciences University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zane","family":"Deliu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q. 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