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Their misregulation is central to many pathologies, and they have therefore been the focus of biomedical research for decades. These proteases have also recently emerged as mediators of neural development and synaptic plasticity in vertebrates, however, understanding of the mechanistic basis of these roles and the molecular identities of the MMPs involved remains far from complete. We have identified a zebrafish orthologue of <jats:italic>mmp25<\/jats:italic> (a.k.a. leukolysin; MT6\u2010MMP), a membrane\u2010type, furin\u2010activated MMP associated with leukocytes and invasive carcinomas, but which we find is expressed by a subset of the sensory neurons during normal embryonic development. We detect high levels of <jats:italic>Mmp25\u03b2<\/jats:italic> expression in the trigeminal, craniofacial, and posterior lateral line ganglia in the hindbrain, and in Rohon\u2010Beard cells in the dorsal neural tube during the first 48 h of embryonic development. Knockdown of Mmp25\u03b2 expression with morpholino oligonucleotides results in larvae that are uncoordinated and insensitive to touch, and which exhibit defects in the development of sensory neural structures. Using in vivo zymography, we observe that Mmp25\u03b2 morphant embryos show reduced Type IV collagen degradation in regions of the head traversed by elongating axons emanating from the trigeminal ganglion, suggesting that Mmp25\u03b2 may play a pivotal role in mediating ECM remodeling in the vicinity of these elongating axons. genesis 52:833\u2013848, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvg.22803","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T09:51:55Z","timestamp":1406713915000},"page":"833-848","source":"Crossref","is-referenced-by-count":14,"title":["Mmp25\u03b2 facilitates elongation of sensory neurons during zebrafish development"],"prefix":"10.1002","volume":"52","author":[{"given":"Bryan D.","family":"Crawford","sequence":"first","affiliation":[{"name":"Department of Biology University of New Brunswick New Brunswick Canada"},{"name":"Department of Biological Sciences University of Alberta Alberta 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