{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T13:19:46Z","timestamp":1775999986933,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T00:00:00Z","timestamp":1426032000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The cuticle of the nematode <jats:italic>Caenorhabditis elegans<\/jats:italic> is a specialized extracellular matrix whose major component is collagen. Cuticle collagens are encoded by a large multigene family consisting of more than 150 members. Cuticle collagen genes are expressed in epidermis (hypodermis) and may be stage\u2010specific or cyclically expressed. We identified cuticle collagen genes as transcriptional targets of the DBL\u20101 TGF\u2010\u03b2\u2010related signaling pathway. These studies prompted us to investigate the <jats:italic>cis<\/jats:italic>\u2010regulatory sequences required for transcription of one of the target genes, <jats:italic>col\u201041<\/jats:italic>. We generated reporter constructs that reproduce stage\u2010 and tissue\u2010specific expression of fluorescent markers. We identify four conserved sequence elements that are required for transcription of reporters. Finally, we provide evidence that <jats:italic>col\u201041<\/jats:italic> expression is controlled by a sequence element containing two GATA sites and by the epidermal GATA transcription factors ELT\u20101 and ELT\u20103. genesis 53:278\u2013284, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvg.22847","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T04:41:00Z","timestamp":1424752860000},"page":"278-284","source":"Crossref","is-referenced-by-count":24,"title":["Multiple <i>cis<\/i> elements and GATA factors regulate a cuticle collagen gene in <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1002","volume":"53","author":[{"given":"Jianghua","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Biology Queens College CUNY, Flushing New York"},{"name":"The Graduate Center CUNY, New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uday","family":"Madaan","sequence":"additional","affiliation":[{"name":"Department of Biology Queens College CUNY, Flushing New York"},{"name":"The Graduate Center CUNY, New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biology Queens College CUNY, Flushing New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelum","family":"Aftab","sequence":"additional","affiliation":[{"name":"Department of Biology Queens College CUNY, Flushing New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3457-0509","authenticated-orcid":false,"given":"Cathy","family":"Savage\u2010Dunn","sequence":"additional","affiliation":[{"name":"Department of Biology Queens College CUNY, Flushing New York"},{"name":"The Graduate Center CUNY, New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,11]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502681200"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2004.10.002"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506882200"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196914"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.4.2301"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.7.2533-2544.2001"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9202"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.2144\/02324bm01"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.113.009522"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00732.x"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01278"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2012.03.006"},{"key":"e_1_2_2_14_1","first-page":"4373","article-title":"Using RNA\u2010mediated interference feeding strategy to screen for genes involved in body size regulation in the nematode C. elegans","volume":"72","author":"Liang J","year":"2013","journal-title":"J Vis Exp"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.02.038"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb04966.x"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.114587.110"},{"key":"e_1_2_2_18_1","doi-asserted-by":"crossref","unstructured":"PageAP JohnstoneIL.2007.The cuticle. 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