{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:56:06Z","timestamp":1791327366744,"version":"4.3.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,17]],"date-time":"2016-01-17T00:00:00Z","timestamp":1452988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"March of Dimes Birth Defects Foundation"},{"name":"Institutional core services","award":["5P30GM103392 and 5P30GM106391."],"award-info":[{"award-number":["5P30GM103392 and 5P30GM106391."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The ductus arteriosus is an arterial vessel that shunts blood flow away from the lungs during fetal life, but normally occludes after birth to establish the adult circulation pattern. Failure of the ductus arteriosus to close after birth is termed patent ductus arteriosus, and is one of the most common congenital heart defects. Our previous work demonstrated that vascular smooth muscle cell expression of the <jats:italic>Jag1<\/jats:italic> gene, which encodes a ligand for Notch family receptors, is essential for postnatal closure of the ductus arteriosus in mice. However, it was not known what cell population was responsible for receiving the <jats:italic>Jag1<\/jats:italic>\u2010mediated signal. Here we show, using smooth muscle cell\u2010specific deletion of the <jats:italic>Rbpj<\/jats:italic> gene, which encodes a transcription factor that mediates all canonical Notch signaling, that Notch signal reception in the vascular smooth muscle cell compartment is required for ductus arteriosus closure. These data indicate that homotypic vascular smooth muscle cell interactions are required for proper contractile smooth muscle cell differentiation and postnatal closure of the ductus arteriosus in mice. genesis 54:86\u201390, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvg.22916","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T05:29:46Z","timestamp":1452230986000},"page":"86-90","source":"Crossref","is-referenced-by-count":19,"title":["Notch signal reception is required in vascular smooth muscle cells for ductus arteriosus closure"],"prefix":"10.1002","volume":"54","author":[{"given":"Luke T.","family":"Krebs","sequence":"first","affiliation":[{"name":"Center for Molecular Medicine Maine Medical Center Research Institute Scarborough Maine 04074"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine R.","family":"Norton","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine Maine Medical Center Research Institute Scarborough Maine 04074"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gridley","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine Maine Medical Center Research Institute Scarborough Maine 04074"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,17]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2013.05.006"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22904"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00081"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2011.09.018"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.052043"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(10)92009-7"},{"key":"e_1_2_2_8_1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1007\/s00246-001-0076-1","article-title":"Successful combined orthotopic liver transplant and transcatheter management of atrial septal defect, patent ductus arteriosus, and peripheral pulmonic stenosis in a small infant with Alagille syndrome","volume":"23","author":"Harris M","year":"2002","journal-title":"Pediatr Cardiol"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102650499"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-0899-4_16"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2014.09.004"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.047159"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1929"},{"key":"e_1_2_2_14_1","first-page":"418","article-title":"Alagille syndrome and isolated persistent ductus arteriosus","volume":"20","author":"Sanchez\u2010Angulo JI","year":"1997","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.592063"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni793"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.181"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00469-5"}],"container-title":["genesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvg.22916","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvg.22916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:40:32Z","timestamp":1695541232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dvg.22916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,17]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1002\/dvg.22916"],"URL":"https:\/\/doi.org\/10.1002\/dvg.22916","archive":["Portico"],"relation":{},"ISSN":["1526-954X","1526-968X"],"issn-type":[{"value":"1526-954X","type":"print"},{"value":"1526-968X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,17]]}}}