{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T21:10:13Z","timestamp":1771103413796,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"KAKENHI","award":["#26462781 (to M.A.)"],"award-info":[{"award-number":["#26462781 (to M.A.)"]}]},{"name":"KAKENHI","award":["#15H06388 (to J.F.)"],"award-info":[{"award-number":["#15H06388 (to J.F.)"]}]},{"name":"Egyptian Government Fellowship (to A.G.N.)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Tricho\u2010rhino\u2010phalangeal syndrome (TRPS) is a rare congenital disorder that is characterized by abnormal hair growth and skeletal deformities. These result in sparse hair, short stature, and early onset of joint problems. Recent reports have shown that a relatively high proportion of patients with TRPS exhibit a broad range of congenital heart defects. To determine the regulation of Trps1 transcription <jats:italic>in vivo<\/jats:italic>, we generated novel transgenic mice, which expressed Cre recombinase under the murine Trps1 proximal promoter sequence (Trps1\u2010Cre). We crossed these mice with Cre reporter mice to identify Trps1 daughter cells. Labeled cells were observed in the appendicular joint tissue, dermal papilla of the hair follicles, cardiac valves, aortic sinus, atrial walls, and the interventricular septum. <jats:italic>In situ<\/jats:italic> analysis showed restricted <jats:italic>Trps1<\/jats:italic> expression, which was observed in endocardial cushions of the outflow tract, and in leaflets of all mature cardiac valves. These results suggest that the Trps1 proximal promoter sequence contains some of the tissue\u2010specific Trps1 regulatory region. Further, our findings partially explain why patients with TRPS show a broad range of congenital cardiac defects, although <jats:italic>Trps1<\/jats:italic> expression is observed in a more restricted fashion. genesis 54:379\u2013388, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvg.22951","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T15:26:47Z","timestamp":1464967607000},"page":"379-388","source":"Crossref","is-referenced-by-count":4,"title":["Fate mapping of Trps1 daughter cells during cardiac development using novel Trps1\u2010Cre mice"],"prefix":"10.1002","volume":"54","author":[{"given":"Ahmed G.","family":"Nomir","sequence":"first","affiliation":[{"name":"Department of Oral Anatomy and Developmental Biology Osaka University Graduate School of Dentistry Suita Osaka Japan"},{"name":"Department of Anatomy and Embryology, Faculty of Veterinary Medicine Damnhour University  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Developmental Biology Osaka University Graduate School of Dentistry Suita Osaka Japan"},{"name":"Department of Orthodontics Osaka University Graduate School of Dentistry Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Fujikawa","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Developmental Biology Osaka University Graduate School of Dentistry Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf A.","family":"El Sharaby","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Veterinary Medicine Damnhour University  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Wakisaka","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Developmental Biology Osaka University Graduate School of Dentistry Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Developmental Biology Osaka University Graduate School of Dentistry Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.11.022"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.062237ma"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401711101"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","unstructured":"BrewerS JiangX DonaldsonS WilliamsT SucovHM.2002. 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