{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T20:03:00Z","timestamp":1776542580128,"version":"3.51.2"},"reference-count":86,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T00:00:00Z","timestamp":1466726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH\u2010NIDCR\u2010R01DE01870 (R.P.A.) R01DE01870; NIH\u2010R01CA160356 (P.S.), R01CA193677 (P.S.)."],"award-info":[{"award-number":["NIH\u2010NIDCR\u2010R01DE01870 (R.P.A.) 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We used available human DNase\u2010seq and histone modification ChiP\u2010seq data on various cell\u2010types to demonstrate that genes in the fibroblast cell identity signature can be epigenetically repressed in other cell\u2010types. We found a subset of the signature genes whose expression is dependent on Wnt\/\u03b2\u2010catenin activity <jats:italic>in vivo<\/jats:italic>. With our approach, we have defined and validated a statistically derived gene expression signature that may mediate dermal fibroblast identity and function in development and disease. genesis 54:415\u2013430, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvg.22952","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T08:26:48Z","timestamp":1465201608000},"page":"415-430","source":"Crossref","is-referenced-by-count":24,"title":["Defining the identity of mouse embryonic dermal fibroblasts"],"prefix":"10.1002","volume":"54","author":[{"given":"Isadore","family":"Budnick","sequence":"first","affiliation":[{"name":"Department of Biology Case Western Reserve University Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Hamburg\u2010Shields","sequence":"additional","affiliation":[{"name":"Department of Biology Case Western Reserve University Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biology Case Western Reserve University Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Torre","sequence":"additional","affiliation":[{"name":"Epithelial Biology Program, Department of Dermatology Stanford University  California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Jarrell","sequence":"additional","affiliation":[{"name":"Department of Biology Case Western Reserve University Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batool","family":"Akhtar\u2010Zaidi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of California Irvine, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Cordovan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of California Irvine, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob C.","family":"Spitale","sequence":"additional","affiliation":[{"name":"Epithelial Biology Program, Department of Dermatology Stanford University  California"},{"name":"Department of Genetics and Genome Sciences Case Western Reserve University Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Scacheri","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of California Irvine, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhika P.","family":"Atit","sequence":"additional","affiliation":[{"name":"Department of Biology Case Western Reserve University Cleveland Ohio"},{"name":"Department of Pharmaceutical Sciences University of California Irvine, California"},{"name":"Department of Dermatology Case Western Reserve University Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00167-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119065"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.04.449"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006437108"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.001"},{"key":"e_1_2_7_9_1","unstructured":"BernsteinBE MikkelsenTS XieX KamalM HuebertDJ CuffJ FryB MeissnerA WernigM PlathK JaenischR WagschalA FeilR SchreiberSL LanderES.2006.A bivalent chromatin structure marks key developmental genes in embryonic stem cells. 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