{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T07:40:39Z","timestamp":1695800439464},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T00:00:00Z","timestamp":1478908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["37850"],"award-info":[{"award-number":["37850"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>Neurotrophin receptor associated death domain<\/jats:italic> gene (<jats:italic>Nradd\/Nrh2\/Plaidd<\/jats:italic>) is a type I transmembrane protein with a unique and short N\u2010terminal extracellular domain and a transmembrane and intracellular domain that bears high similarity to the p75 neurotrophin receptor (<jats:italic>p75NTR\/Ngfr<\/jats:italic>). Initial studies suggested that NRADD regulates neurotrophin signaling but very little is known about its physiological roles. We have generated and characterized NRADD conditional and germ\u2010line null mouse lines. These mice are viable and fertile and do\u0144t show evident abnormalities. However, NRADD deletion results in an increase in the proportion of dorsal root ganglion neurons expressing p75NTR. The NRADD conditional and complete knockout mouse lines generated are new and useful tools to study the physiological roles of NRADD. Birth Defects Research (Part A) 106:605\u2013612, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dvg.22989","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T14:52:41Z","timestamp":1477320761000},"page":"605-612","source":"Crossref","is-referenced-by-count":1,"title":["Generation and characterization of mice bearing null alleles of nradd\/Nrh2"],"prefix":"10.1002","volume":"54","author":[{"given":"Nicolas","family":"Unsain","sequence":"first","affiliation":[{"name":"Laboratorio de Neurobiolog\u00eda, Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra INIMEC\u2010CONICET, Universidad Nacional de C\u00f3rdoba Friuli 2434 C\u00f3rdoba 5016 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevieve","family":"Dorval","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute, McGill University 3801 University Street Montreal QCH3A 2B4 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hyung","family":"Sheen","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute, McGill University 3801 University Street Montreal QCH3A 2B4 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip A","family":"Barker","sequence":"additional","affiliation":[{"name":"Vice Principal Research University of British Columbia Okanagan Campus, 3247 University Way Kelowna British Columbia V1V1V7 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-45106-5_1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:1:3:153"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-45106-5_8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01263"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02513.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-13-05425.2003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.118"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-45106-5_6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90286-L"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/337362a0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1990.tb00431.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.749203"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.04.027"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"6988","DOI":"10.1523\/JNEUROSCI.17-18-06988.1997","article-title":"Transgenic mice expressing the intracellular domain of the p75 neurotrophin receptor undergo neuronal apoptosis","volume":"17","author":"Majdan M.","year":"1997","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3960-03.2004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00016-3"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069286"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980323)392:4<489::AID-CNE6>3.0.CO;2-X"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401208"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092310411"}],"container-title":["genesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvg.22989","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvg.22989","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvg.22989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T13:42:38Z","timestamp":1695735758000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dvg.22989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,12]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1002\/dvg.22989"],"URL":"https:\/\/doi.org\/10.1002\/dvg.22989","archive":["Portico"],"relation":{},"ISSN":["1526-954X","1526-968X"],"issn-type":[{"value":"1526-954X","type":"print"},{"value":"1526-968X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,12]]}}}