{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:48:20Z","timestamp":1753868900543,"version":"3.41.2"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:00:00Z","timestamp":1500422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["16H06371","17H05935","15K14306","16H02452"],"award-info":[{"award-number":["16H06371","17H05935","15K14306","16H02452"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["201540170"],"award-info":[{"award-number":["201540170"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Drosophila<\/jats:italic> Btk29A is a Tec family nonreceptor tyrosine kinase, the ortholog of which causes X\u2010linked agammaglobulinemia in humans when mutant. In <jats:italic>Btk29A<jats:sup>ficP<\/jats:sup><\/jats:italic> mutant ovaries, multiple defects are observed: extrapolar cells form ectopically; <jats:italic>osk<\/jats:italic> mRNA fails to accumulate posteriorly in mature oocytes; the shape and alignment of follicle cells are grossly distorted. All these phenotypes are rescued by selectively overexpressing the type 2 isoform of wild\u2010type <jats:italic>Btk29A<\/jats:italic> in follicle cells. Expression of certain proteins enriched in adherens junctions is markedly affected in <jats:italic>Btk29A<jats:sup>ficP<\/jats:sup><\/jats:italic> mutants; the anterior\u2013posterior gradient normally observed in the expression of <jats:italic>D<\/jats:italic>E\u2010Cadherin and Armadillo are lost and Canoe is sequestered from adherens junctions. Intriguingly, tyrosine phosphorylation of Canoe is reduced in <jats:italic>Btk29A<jats:sup>ficP<\/jats:sup><\/jats:italic> mutants. It is proposed that <jats:italic>Btk29A<\/jats:italic> is required for the establishment of egg chamber polarity presumably through the regulation of subcellular localization of its downstream proteins, including Cno.<\/jats:p>","DOI":"10.1002\/dvg.23042","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T06:42:37Z","timestamp":1498113757000},"source":"Crossref","is-referenced-by-count":2,"title":["Ovarian polarity and cell shape determination by Btk29A in <i>Drosophila<\/i>"],"prefix":"10.1002","volume":"55","author":[{"given":"Noriko","family":"Hamada\u2010Kawaguchi","sequence":"first","affiliation":[{"name":"Division of Neurogenetics Tohoku University Graduate School of Life Sciences Katahira, Aoba\u2010ku Sendai 980\u20108577 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4623-0106","authenticated-orcid":false,"given":"Daisuke","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Neurogenetics Tohoku University Graduate School of Life Sciences Katahira, Aoba\u2010ku Sendai 980\u20108577 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,19]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1331","volume-title":"A Laboratory Handbook","author":"Ashburner M.","year":"1989"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/01677060701249488"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.6.4405"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.032391"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.07.049"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01926"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.031"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119.4.1359"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.05.012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01938"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.09.021"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1242\/dev.128.16.3209","article-title":"The receptor\u2010like tyrosine phosphatase Lar is required epithelial planar polarity and for axis determination within Drosophila ovarian follicles","volume":"128","author":"Frydman H. 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