{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:55:04Z","timestamp":1778543704724,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["22123005"],"award-info":[{"award-number":["22123005"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16GS0311"],"award-info":[{"award-number":["16GS0311"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Reck<\/jats:italic> encodes a membrane\u2010anchored glycoprotein implicated in the regulation of extracellular metalloproteinases, Notch\u2010signaling, and Wnt7\u2010signaling and shown to play critical roles in embryogenesis and tumor suppression. Precise mechanisms of its actions <jats:italic>in vivo<\/jats:italic>, however, remain largely unknown. By homologous recombination, we generated a new <jats:italic>Reck<\/jats:italic> allele, <jats:italic>Reck<jats:sup>CreERT2<\/jats:sup><\/jats:italic> (MGI symbol: Reck&lt;tm3.1(cre\/ERT2)Noda&gt;). This allele is defective in terms of <jats:italic>Reck<\/jats:italic> function but expected to induce loxP\u2010mediated recombination in the cells committed to express <jats:italic>Reck<\/jats:italic>. Similarity in the expression patterns of the <jats:italic>Reck<jats:sup>CreERT2<\/jats:sup><\/jats:italic> transgene and the endogenous <jats:italic>Reck<\/jats:italic> gene was confirmed in five tissues. In the adult hippocampus, induction of <jats:italic>Reck<\/jats:italic> expression after transient cerebral ischemia could be demonstrated using this allele. These results indicate the utility of this Cre\u2010driver allele in further studies.<\/jats:p>","DOI":"10.1002\/dvg.23099","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T08:33:27Z","timestamp":1520325207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Generation and characterization of a mouse line carrying <i>Reck\u2010CreERT2<\/i> knock\u2010in allele"],"prefix":"10.1002","volume":"56","author":[{"given":"Tomoko","family":"Matsuzaki","sequence":"first","affiliation":[{"name":"Department of Molecular Oncology Kyoto University Graduate School of Medicine, Yoshida\u2010Konoe\u2010cho Sakyo\u2010ku Kyoto 606\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology Kyoto University Graduate School of Medicine, Yoshida\u2010Konoe\u2010cho Sakyo\u2010ku Kyoto 606\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology Kyoto University Graduate School of Medicine, Yoshida\u2010Konoe\u2010cho Sakyo\u2010ku Kyoto 606\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunya","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology Kyoto University Graduate School of Medicine, Yoshida\u2010Konoe\u2010cho Sakyo\u2010ku Kyoto 606\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichiro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology Kyoto University Graduate School of Medicine, Yoshida\u2010Konoe\u2010cho Sakyo\u2010ku Kyoto 606\u20108501 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