{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:54:40Z","timestamp":1790711680107,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"6-7","license":[{"start":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T00:00:00Z","timestamp":1533686400000},"content-version":"vor","delay-in-days":68,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Association Fran\u00e7aise contre les Myopathies, Fondation Lefoulon-Delalande"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Members of the large family of Hox transcription factors are encoded by genes whose tightly regulated expression in development and in space within different embryonic tissues confer positional identity from the neck to the tips of the limbs. Many structures of the face, head, and heart develop from cell populations expressing few or no\n                    <jats:italic>Hox<\/jats:italic>\n                    genes.\n                    <jats:italic>Hoxb1<\/jats:italic>\n                    is the member of its chromosomal cluster expressed in the most rostral domain during vertebrate development, but never by the multipotent neural crest cell population anterior to the cerebellum. We have developed a novel floxed transgenic mouse line,\n                    <jats:italic>CAG\u2010Hoxb1,\u2010EGFP<\/jats:italic>\n                    (\n                    <jats:italic>CAG\u2010Hoxb1<\/jats:italic>\n                    ), which upon recombination by Cre recombinase conditionally induces robust\n                    <jats:italic>Hoxb1<\/jats:italic>\n                    and\n                    <jats:italic>eGFP<\/jats:italic>\n                    overexpression. When induced within the neural crest lineage, pups die at birth. A variable phenotype develops from E11.5 on, associating frontonasal hypoplasia\/aplasia, micrognathia\/agnathia, major ocular and forebrain anomalies, and cardiovascular malformations. Neural crest derivatives in the body appear unaffected. Transcription of effectors of developmental signaling pathways (Bmp, Shh, Vegfa) and transcription factors (Pax3, Sox9) is altered in mutants. These outcomes emphasize that repression of\n                    <jats:italic>Hoxb1<\/jats:italic>\n                    , along with other paralog group 1 and 2\n                    <jats:italic>Hox<\/jats:italic>\n                    genes, is strictly necessary in anterior cephalic NC for craniofacial, visual, auditory, and cardiovascular development.\n                  <\/jats:p>","DOI":"10.1002\/dvg.23221","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T11:31:19Z","timestamp":1533727879000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Ectopic expression of\n                    <i>Hoxb1<\/i>\n                    induces cardiac and craniofacial malformations"],"prefix":"10.1002","volume":"56","author":[{"given":"St\u00e9phane","family":"Zaffran","sequence":"first","affiliation":[{"name":"Aix Marseille Univ, MMG, INSERM  Marseille U1251 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Odelin","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, MMG, INSERM  Marseille U1251 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Stefanovic","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, MMG, INSERM  Marseille U1251 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Lescroart","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, MMG, INSERM  Marseille U1251 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0201-3799","authenticated-orcid":false,"given":"Heather C.","family":"Etchevers","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, MMG, INSERM  Marseille U1251 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)80052-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1242\/dev.122.3.735","article-title":"Ectopic expression of Hoxa\u20101 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid\u2010induced phenotype","volume":"122","author":"Alexandre 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