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Genetic analyses have been very successful in identifying pathogenic mutations, however, model organisms are required to characterize how these mutations affect embryonic development thereby leading to complex clinical conditions. The African clawed frog <jats:italic>Xenopus laevis<\/jats:italic> provides a broad range of in vivo and in vitro tools allowing for a detailed characterization of NC development. Due to the conserved nature of craniofacial morphogenesis in vertebrates, <jats:italic>Xenopus<\/jats:italic> is an efficient and versatile system to dissect the morphological and cellular phenotypes as well as the signaling events leading to NC defects. Here, we review a set of techniques and resources how <jats:italic>Xenopus<\/jats:italic> can be used as a disease model to investigate the pathogenesis of Kabuki syndrome and neurocristopathies in a wider sense.<\/jats:p>","DOI":"10.1002\/dvg.23404","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T03:27:28Z","timestamp":1608694048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Using <i>Xenopus<\/i> to analyze neurocristopathies like Kabuki syndrome"],"prefix":"10.1002","volume":"59","author":[{"given":"Janina","family":"Schwenty\u2010Lara","sequence":"first","affiliation":[{"name":"Department of Biology, Molecular Embryology Philipps\u2010University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Pauli","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2524-5384","authenticated-orcid":false,"given":"Annette","family":"Borchers","sequence":"additional","affiliation":[{"name":"Department of Biology, Molecular Embryology Philipps\u2010University Marburg  Marburg Germany"},{"name":"DFG Research Training Group, Membrane Plasticity in Tissue Development and Remodeling, GRK 2213 Philipps\u2010University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2004.00348.x"},{"volume-title":"Kabuki Syndrome. 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