{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:16:38Z","timestamp":1791987398405,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"10-12","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD087589"],"award-info":[{"award-number":["R21HD087589"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD096266"],"award-info":[{"award-number":["R01HD096266"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>All mammalian uteri contain glands in their endometrium that develop only or primarily after birth. In mice, those endometrial glands govern post implantation pregnancy establishment via regulation of blastocyst implantation, stromal cell decidualization, and placental development. Here, we describe a new uterine glandular epithelium (GE) specific Cre recombinase mouse line that is useful for the study of uterine gland function during pregnancy. Utilizing CRISPR\u2010Cas9 genome editing, Cre recombinase was inserted into the endogenous serine protease 29 precursor (<jats:italic>Prss29<\/jats:italic>) gene. Both <jats:italic>Prss29<\/jats:italic> mRNA and Cre recombinase activity was specific to the GE of the mouse uterus following implantation, but was absent from other areas of the female reproductive tract. Next, <jats:italic>Prss29\u2010Cre<\/jats:italic> mice were crossed with floxed forkhead box A2 (<jats:italic>Foxa2<\/jats:italic>) mice to conditionally delete Foxa2 specifically in the endometrial glands. Foxa2 was absent in the glands of the post\u2010implantation uterus, and Foxa2 deleted mice exhibited complete infertility after their first pregnancy. These results establish that <jats:italic>Prss29\u2010Cre<\/jats:italic> mice are a valuable resource to elucidate and explore the functions of glands in the adult uterus.<\/jats:p>","DOI":"10.1002\/dvg.23493","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T13:49:30Z","timestamp":1658497770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp><i>Prss29 Cre<\/i><\/scp> recombinase mice are useful to study adult uterine gland function"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1484-4998","authenticated-orcid":false,"given":"Andrew M.","family":"Kelleher","sequence":"first","affiliation":[{"name":"Division of Animal Sciences University of Missouri  Columbia Missouri USA"},{"name":"Department of Obstetrics, Gynecology and Women's Health University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn C.","family":"Allen","sequence":"additional","affiliation":[{"name":"Division of Animal Sciences University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Davis","sequence":"additional","affiliation":[{"name":"Animal Modeling Core, University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-766X","authenticated-orcid":false,"given":"Thomas E.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Division of Animal Sciences University of Missouri  Columbia Missouri USA"},{"name":"Department of Obstetrics, Gynecology and Women's Health University of Missouri  Columbia Missouri 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