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Importantly, the limited regeneration capacity of the periodontium could be improved with the development of novel biomaterials and therapeutic strategies. Of note, the regenerative potential of the periodontium depends not only on its tissue\u2010specific architecture and function, but also on its ability to reconstruct distinct tissues and tissue interfaces, suggesting that the advancement of tissue engineering approaches can ultimately offer new perspectives to promote the organized reconstruction of soft and hard periodontal tissues. Here, we discuss material\u2010based, biologically active cues, and the application of innovative biofabrication technologies to regenerate the multiple tissues that comprise the periodontium.<\/jats:p>","DOI":"10.1002\/dvg.23501","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T21:09:40Z","timestamp":1663362580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Advanced biomaterials for periodontal tissue regeneration"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8328-1818","authenticated-orcid":false,"given":"Arwa","family":"Daghrery","sequence":"first","affiliation":[{"name":"Department of Restorative Dental Sciences, School of Dentistry Jazan University  Jazan Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8740-2464","authenticated-orcid":false,"given":"Marco 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