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Various transgenic Cre lines have been developed to facilitate studying gene function in specific tissues. In this study, we have characterized the expression pattern of <jats:italic>Six2Cre<\/jats:italic> mice at multiple stages during craniofacial development. Our data revealed that <jats:italic>Six2Cre<\/jats:italic> lineage cells are predominantly present in frontal bone, mandible, and secondary palate. Using immunostaining method, we found that <jats:italic>Six2Cre<\/jats:italic> triggered reporter is co\u2010expressed with Runx2. In summary, our data showed <jats:italic>Six2Cre<\/jats:italic> can be used to study gene function during palate development and osteogenesis in mouse models.<\/jats:p>","DOI":"10.1002\/dvg.23516","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T10:53:59Z","timestamp":1680260039000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterizing expression pattern of <scp><i>Six2Cre<\/i><\/scp> during mouse craniofacial development"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-2274","authenticated-orcid":false,"given":"Meenakshi","family":"Umar","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology, School of Science and Engineering Tulane University  New Orleans Louisiana 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