{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:52:15Z","timestamp":1754110335285,"version":"3.41.2"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Although epithelial\u2013mesenchymal markers play an important role in prostate cancer (PC), further research is needed to better understand their utility in diagnosis, cancer progression prevention, and treatment resistance prediction. Our study included 111 PC patients who underwent transurethral resection, as well as 16 healthy controls. Reverse transcription\u2010quantitative polymerase chain reaction (RT\u2010qPCR) was used to examine the expression of E\u2010cadherin, \u03b2\u2010catenin, and Vimentin. We found that E\u2010cadherin and \u03b2\u2010catenin were underexpressed in primary PC tissues. E\u2010cadherin expression was found to be inversely associated with prostate\u2010specific antigen progression (PSA\u2010P; serum marker of progression; <jats:italic>p<\/jats:italic>\u2009=\u20090.01; |r|\u2009=\u20090.262). Furthermore, the underexpression of two markers, E\u2010cadherin and \u03b2\u2010catenin, was found to be associated with advanced tumor stage and grade (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). On the other hand, Vimentin was overexpressed in PC patients with a fold change of 2.141, and it was associated with the diagnosis, prognosis, and prediction of treatment resistance to androgen deprivation therapy (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), abiraterone\u2010acid (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), and taxanes (<jats:italic>p<\/jats:italic>\u2009=\u20090.029). Moreover, the current study highlighted that poor survival could be significantly found in patients who progressed after primary surgery, did not use drugs, and expressed these genes aberrantly. In Cox regression multivariate analysis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), a positive correlation between the Vimentin marker and coronary heart disease in PC patients was identified (<jats:italic>p<\/jats:italic>\u2009=\u20090.034). In summary, the present study highlights the diagnostic (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), prognostic (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and therapeutic potential of Vimentin in primary PC (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), as well as its implications for cardiovascular disease. Furthermore, we confirm the potential prognostic value of E\u2010cadherin and \u03b2\u2010catenin.<\/jats:p>","DOI":"10.1002\/dvg.23543","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T05:56:48Z","timestamp":1693461408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Correlation between <scp>E<\/scp>\u2010cadherin\/\u03b2\u2010catenin, Vimentin expression, clinicopathologic features and drug resistance prediction in na\u00efve prostate cancer: A molecular and clinical study"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6212-3637","authenticated-orcid":false,"given":"Rahma","family":"Said","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Engineering, Laboratory of Protein Engineering and Bio\u2010active Molecules, National Institute of Applied Science and Technology University of Carthage  Tunis Tunisia"},{"name":"Department of Pathology, Molecular Biology Laboratory Hospital Universitari Vall d'Hebron  Barcelona Spain"},{"name":"Higher Institute of Biotechnology of Beja University of Jendouba  Jendouba Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Hern\u00e1ndez\u2010Losa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular Biology Laboratory Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amine","family":"Derouiche","sequence":"additional","affiliation":[{"name":"Urology Department Charles Nicolle Hospital  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Moline","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular Biology Laboratory Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Somoza Lopez","family":"de Haro","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular Biology Laboratory Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Skander","family":"Zouari","sequence":"additional","affiliation":[{"name":"Urology Department Charles Nicolle Hospital  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahlem","family":"Blel","sequence":"additional","affiliation":[{"name":"Pathology Anatomy and Cytology Department Charles Nicolle Hospital  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumaya","family":"Rammeh","sequence":"additional","affiliation":[{"name":"Pathology Anatomy and Cytology Department Charles Nicolle Hospital  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slah","family":"Ouerhani","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, Laboratory of Protein Engineering and Bio\u2010active Molecules, National Institute of Applied Science and Technology University of Carthage  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405095"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.09.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-021-00299-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-021-03063-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.10.013"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.07.022"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00499"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30560-5"},{"issue":"6","key":"e_1_2_10_10_1","article-title":"Cardiovascular effects of androgen deprivation therapy in prostate cancer patients: A systematic review","volume":"14","author":"Kakarla M.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2017.10.014"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7938280"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12024-z"},{"issue":"1","key":"e_1_2_10_14_1","first-page":"168","article-title":"Vimentin and Ki67 expression in circulating tumour cells derived from castrate\u2010resistant prostate cancer","volume":"16","author":"Lindsay C. R.","year":"2016","journal-title":"BioMed Central Cancer"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.160"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8101118"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-21-0098"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1918167117"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00370"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5173\/ceju.2012.03.art4"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2020-0043"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112795"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209096"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.afju.2016.02.007"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17632"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14711"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207506"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v6.i4.64"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15687"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.261933"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2003892"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20109"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-015-0161-6"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13194985"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-017-0203-x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15300"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-136994"}],"container-title":["genesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvg.23543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T06:51:30Z","timestamp":1709103090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dvg.23543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,30]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/dvg.23543"],"URL":"https:\/\/doi.org\/10.1002\/dvg.23543","archive":["Portico"],"relation":{},"ISSN":["1526-954X","1526-968X"],"issn-type":[{"type":"print","value":"1526-954X"},{"type":"electronic","value":"1526-968X"}],"subject":[],"published":{"date-parts":[[2023,8,30]]},"assertion":[{"value":"2023-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23543"}}