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In the eye, it is not known how <jats:italic>Pax2<\/jats:italic> expression is regulated and progressively restricted, in part because no <jats:italic>Pax2<\/jats:italic> regulatory elements have been identified for this organ. Multiple Pax2\u2010Cre mouse transgenic lines have been produced, but essentially none of these Cre recombinase drivers are active in the visual system. Only Tg(BAC\u2010Pax2\u2010cre)<jats:sup>Akg<\/jats:sup> mice have been reported to express Cre in a subset of postnatal retinal astrocytes. We confirm this observation and demonstrate ectopic expression in branchial arches, extraocular muscles, and a subset of GABAergic amacrine cells. Our findings suggest that major eye enhancer(s) for mouse <jats:italic>Pax2<\/jats:italic> reside outside the &gt;\u2009180\u2009kb genomic segment delimited by <jats:italic>Pax2<\/jats:italic> BAC transgenes.<\/jats:p>","DOI":"10.1002\/dvg.70016","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T18:30:26Z","timestamp":1745951426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Excluding the Genomic Location of <i>Pax2<\/i> Regulatory Elements for the Developing Mouse Eye"],"prefix":"10.1002","volume":"63","author":[{"given":"Tzu\u2010Hua","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Human Anatomy University of California  Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Santamaria\u2010Munoz","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Human 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