{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:16:36Z","timestamp":1791987396370,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD042311"],"award-info":[{"award-number":["HD042311"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD112315"],"award-info":[{"award-number":["HD112315"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The mammalian uterus contains glands in the endometrium that develop only or primarily after birth. In the mouse, endometrial glands govern post implantation pregnancy establishment via regulation of blastocyst implantation, stromal cell decidualization, and placental development. Here, we describe a new uterine glandular epithelium (GE) specific Cre recombinase mouse line that is useful to study endometrial gland development and function. Utilizing CRISPR\u2010Cas9 genome editing, improved Cre recombinase (iCre) was inserted into the endogenous C\u2010X\u2010C motif chemokine ligand 15 (\n                    <jats:italic>Cxcl15<\/jats:italic>\n                    ) gene.\n                    <jats:italic>Cxcl15<\/jats:italic>\n                    mRNA, Cxcl15 protein, and\n                    <jats:italic>Cxcl15\u2010iCre<\/jats:italic>\n                    recombinase activity were specific to the developing GE of the uterus.\n                    <jats:italic>Cxcl15\u2010iCre<\/jats:italic>\n                    mice were crossed with floxed\n                    <jats:italic>Foxa2<\/jats:italic>\n                    mice to conditionally delete Foxa2 specifically in the glands of the neonatal mouse uterus. This conditional deletion of Foxa2 in the developing neonatal uterus resulted in adult mice that lacked Foxa2 in the GE of the uterus, and the adult mice were infertile. The studies described here establish that\n                    <jats:italic>Cxcl15\u2010iCre<\/jats:italic>\n                    mice are a valuable resource to elucidate and explore mechanisms regulating the development and function of glands in the uterus.\n                  <\/jats:p>","DOI":"10.1002\/dvg.70026","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T12:45:44Z","timestamp":1756730744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Cxcl15 Cre Recombinase Mouse Model Useful to Study Gland Development in the Uterus"],"prefix":"10.1002","volume":"63","author":[{"given":"Andrew M.","family":"Kelleher","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Women's Health University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Im","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Animal Sciences University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greeshma Sai","family":"Bayammagari","sequence":"additional","affiliation":[{"name":"Division of Animal Sciences University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Davis","sequence":"additional","affiliation":[{"name":"Animal Modeling Core University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Women's Health University of Missouri  Columbia Missouri USA"},{"name":"Division of Animal Sciences University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu048"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.5.3362"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2021.12.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.004440"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/frph.2021.811537"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.640319"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014\u20101265"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgeed.2023.1256451"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.111971"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.083154"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201057848\u2010w"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018\u201000281"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201004848\u20108"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618433114"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1268"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13669\u2010017\u20100187\u20101"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107568"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2025.104837"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.6A7121.2007"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20098"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.09.035"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010animal\u2010020518\u2010115321"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2316410120"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124633"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.07.041"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20410"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010019\u20100177\u2010x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22973"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pathmechdis\u2010012419\u2010032654"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013226107"}],"container-title":["genesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvg.70026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T08:19:52Z","timestamp":1763540392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dvg.70026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/dvg.70026"],"URL":"https:\/\/doi.org\/10.1002\/dvg.70026","archive":["Portico"],"relation":{},"ISSN":["1526-954X","1526-968X"],"issn-type":[{"value":"1526-954X","type":"print"},{"value":"1526-968X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70026"}}