{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:01:00Z","timestamp":1773032460188,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014180","name":"Junta de Castilla y Le\u00f3n","doi-asserted-by":"publisher","award":["CSI143P20"],"award-info":[{"award-number":["CSI143P20"]}],"id":[{"id":"10.13039\/501100014180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014180","name":"Junta de Castilla y Le\u00f3n","doi-asserted-by":"publisher","award":["CLU\u20102019\u201002"],"award-info":[{"award-number":["CLU\u20102019\u201002"]}],"id":[{"id":"10.13039\/501100014180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014180","name":"Junta de Castilla y Le\u00f3n","doi-asserted-by":"publisher","award":["CCVC8485"],"award-info":[{"award-number":["CCVC8485"]}],"id":[{"id":"10.13039\/501100014180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Loss of function of the\n                    <jats:italic>Pejvakin (Pjvk)<\/jats:italic>\n                    gene has been associated with deafness induced by cellular stress. This has been postulated to occur due to defective peroxisome biogenesis. Here, we have characterized a novel mouse mutation lacking exon 3 of the\n                    <jats:italic>Pjvk<\/jats:italic>\n                    coding region. A mouse mutant carrying this mutation showed loss of hair cells associated with profound deafness and reduced outer hair cell function. A cell line carrying a deletion of\n                    <jats:italic>Pjvk<\/jats:italic>\n                    exon 3 revealed upregulation of the peroxisomal enzyme catalase upon oxidative stress. In order to further clarify the localization of Pjvk, we introduced amino\u2010 and carboxy\u2010terminal tags in its cDNA which failed to confirm its presence in peroxisomes but is likely to be due to mis\u2010targeting of the protein. Our study thus confirms the requirement of Pjvk for maintenance of hair cells and intact hearing and a specific role in peroxisomes upon exposure to cellular stress.\n                  <\/jats:p>","DOI":"10.1002\/dvg.70041","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:45:13Z","timestamp":1768909513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of a Novel Mouse Mutation of the Deafness Gene\n                    <i>Pejvakin<\/i>"],"prefix":"10.1002","volume":"64","author":[{"given":"Maria Teresa","family":"Marcos\u2010Almaraz","sequence":"first","affiliation":[{"name":"Unidad de Excelencia, Instituto de Biomedicina y Gen\u00e9tica Molecular de Valladolid (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Cient\u00edficas (CSIC)  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca Llorente","family":"Aparicio","sequence":"additional","affiliation":[{"name":"Unidad de Excelencia, Instituto de Biomedicina y Gen\u00e9tica Molecular de Valladolid (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Cient\u00edficas (CSIC)  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"L\u00f3pez\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unidad de Excelencia, Instituto de Biomedicina y Gen\u00e9tica Molecular de Valladolid (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Cient\u00edficas (CSIC)  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Harasztosi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hearing Research Centre T\u00fcbingen (THRC), Molecular Physiology of Hearing, ENT Clinic, University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlies","family":"Knipper","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hearing Research Centre T\u00fcbingen (THRC), Molecular Physiology of Hearing, ENT Clinic, University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"R\u00fcttiger","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hearing Research Centre T\u00fcbingen (THRC), Molecular Physiology of Hearing, ENT Clinic, University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wibke","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hearing Research Centre T\u00fcbingen (THRC), Molecular Physiology of Hearing, ENT Clinic, University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Angel","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"Unidad de Excelencia, Instituto de Biomedicina y Gen\u00e9tica Molecular de Valladolid (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Cient\u00edficas (CSIC)  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-1640","authenticated-orcid":false,"given":"Thomas","family":"Schimmang","sequence":"additional","affiliation":[{"name":"Unidad de Excelencia, Instituto de Biomedicina y Gen\u00e9tica Molecular de Valladolid (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Cient\u00edficas (CSIC)  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915\u2010021\u201001220\u2010z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.07.101"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20510"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2021.03.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1821844116"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.023"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1829"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13010149"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac972"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2014.02.002"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2711\u201016.2017"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2017.05.005"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1179\/1754762812Y.0000000027"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2008.05.009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4975\u201006.2007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079\u2010020\u201000564\u20105"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495\u2010005\u20101885\u20100"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmaa016"}],"container-title":["genesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvg.70041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dvg.70041","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvg.70041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:09:18Z","timestamp":1773029358000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dvg.70041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/dvg.70041"],"URL":"https:\/\/doi.org\/10.1002\/dvg.70041","archive":["Portico"],"relation":{},"ISSN":["1526-954X","1526-968X"],"issn-type":[{"value":"1526-954X","type":"print"},{"value":"1526-968X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]},"assertion":[{"value":"2025-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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