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Uterine glands, highly conserved structures in the mammalian uterus, play critical roles in the establishment and maintenance of pregnancy and have been implicated in the pathogenesis of uterine diseases, including endometrial cancer and endometriosis. Previous studies have shown that Retinol dehydrogenase 1 (\n                    <jats:italic>Rdh1<\/jats:italic>\n                    ) is specifically expressed in the glandular epithelium (GE) from the onset of gland formation through adulthood. In this study, to develop a GE\u2010specific Cre driver line, we generated\n                    <jats:italic>Rdh1\u2010iCre<\/jats:italic>\n                    mice by introducing an improved Cre recombinase (\n                    <jats:italic>iCre<\/jats:italic>\n                    ) into the\n                    <jats:italic>Rdh1<\/jats:italic>\n                    locus using the CRISPR\/Cas9 system. To evaluate the utility of this model,\n                    <jats:italic>Rdh1\u2010iCre<\/jats:italic>\n                    mice were crossed with\n                    <jats:italic>ROSA26\u2010H2B\u2010mCherry<\/jats:italic>\n                    reporter mice, and Cre\u2010dependent reporter expression was analyzed. Robust mCherry fluorescence was observed throughout the uterine glands at 2\u2009weeks after birth, coinciding with the active elongation and branching of the GE. These results demonstrate that the\n                    <jats:italic>Rdh1\u2010iCre<\/jats:italic>\n                    mouse line is a valuable and highly efficient tool for investigating the physiological roles of uterine glands during development and pregnancy, as well as their contribution to the progression of GE\u2010derived uterine diseases.\n                  <\/jats:p>","DOI":"10.1002\/dvg.70068","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:57:15Z","timestamp":1784872635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Generation and Characterization of a\n                    <i>Rdh1\u2010iCre<\/i>\n                    Line to Study Uterine Glandular Biology"],"prefix":"10.1002","volume":"64","author":[{"given":"Mana","family":"Ohtomo","sequence":"first","affiliation":[{"name":"Laboratory of Animal Reproduction, School of Veterinary Medicine Azabu University  Sagamihara Japan"},{"name":"Graduate School of Veterinary Science Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Takarabe","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Reproduction, School of Veterinary Medicine Azabu University  Sagamihara Japan"},{"name":"Graduate School of Veterinary Science Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6691-2448","authenticated-orcid":false,"given":"Takafumi","family":"Namiki","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Reproduction, School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8870-910X","authenticated-orcid":false,"given":"Yui","family":"Kawata","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Reproduction, School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0336-8823","authenticated-orcid":false,"given":"Ryosuke","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Medical Genetics Research Center Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3284-7161","authenticated-orcid":false,"given":"Manabu","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science The University of Tokyo  Minato\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9743-2456","authenticated-orcid":false,"given":"Hisashi","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Molecular Neuroscience, Faculty of Medicine University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Kageyama","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Reproduction, School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7853-5164","authenticated-orcid":false,"given":"Maki","family":"Kamoshita","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Reproduction, School of Veterinary Medicine Azabu University  Sagamihara Japan"},{"name":"Graduate School of Veterinary Science Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7643-7976","authenticated-orcid":false,"given":"Jumpei","family":"Terakawa","sequence":"additional","affiliation":[{"name":"Graduate School of Veterinary Science Azabu University  Sagamihara Japan"},{"name":"Laboratory of Toxicology, School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9398-7358","authenticated-orcid":false,"given":"Junya","family":"Ito","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Reproduction, School of Veterinary Medicine Azabu University  Sagamihara Japan"},{"name":"Graduate School of Veterinary Science Azabu University  Sagamihara Japan"},{"name":"Center for Human and Animal Symbiosis Science Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20753"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.029"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.004440"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201008\u20101274"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014\u20101265"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.091769"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.111971"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.5.1311"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34135"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.23493"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900013R"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018\u201000281"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.70026"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201004848\u20108"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618433114"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960\u20100760(02)00260\u20101"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010019\u201003046\u2010z"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2010.06.007"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1685525"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007630"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_8_23_1","first-page":"51","volume-title":"Current 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