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Most disease management attempts involve fixed interventions accompanied by post hoc outcome assessments focused on success or failure. Though these approaches have led to valuable management advances, there are limitations to both the rate of advancement and amount of information that can be gained. As such, strategies that support more rapid progress are required. Sarcoptic mange, caused by epidermal infection with <jats:italic>Sarcoptes scabiei<\/jats:italic> mites, is a globally emerging and re\u2010emerging panzootic that exemplifies this problem. The bare\u2010nosed wombat (<jats:italic>Vombatus ursinus<\/jats:italic>), a marsupial endemic to southeastern Australia, is impacted by sarcoptic mange throughout its geographic range and enhanced disease management capabilities are needed to improve upon existing in situ methods. We sought to advance in situ wildlife disease management for sarcoptic mange in free\u2010living bare\u2010nosed wombats, implementing an adaptive approach using fluralaner (Bravecto, MSD Animal Health) and a structured process of learning and method\u2010optimisation. By using surveillance of treated wombats to inform real\u2010time management changes, we have demonstrated the efficacy of topically administered fluralaner at 45 and 85\u2009mg\/kg against sarcoptic mange. Importantly, we observed variation in the effects of 45\u2009mg\/kg doses, but through our adaptive approach found that 85\u2009mg\/kg doses consistently reduced mange severity. Through modifying our surveillance program, we also identified individual\u2010level variation in wombat observability and used this to quantify the level of surveillance needed to assess long\u2010term management success. Our adaptive intervention represents the first report of sarcoptic mange management with fluralaner in free\u2010living wildlife and evaluation of its efficacy in situ. This study illustrates how adapting interventions in real time can advance wildlife disease management and may be applicable to accelerating in situ improvements for other host\u2013pathogen systems.<\/jats:p>","DOI":"10.1002\/eap.3019","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T03:24:28Z","timestamp":1722914668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adaptive interventions for advancing in situ wildlife disease management"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5620-2646","authenticated-orcid":false,"given":"Vicky","family":"Wilkinson","sequence":"first","affiliation":[{"name":"School of Natural Sciences, University of Tasmania  Hobart Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane A.","family":"Richards","sequence":"additional","affiliation":[{"name":"School of Natural Sciences, University of Tasmania  Hobart Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Burgess","sequence":"additional","affiliation":[{"name":"School of Natural Sciences, University of Tasmania  Hobart Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"N\u00e6sborg\u2010Nielsen","sequence":"additional","affiliation":[{"name":"School of Natural Sciences, University of Tasmania  Hobart Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Gutwein","sequence":"additional","affiliation":[{"name":"Mange Management Inc.  St Andrews Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolandi","family":"Vermaak","sequence":"additional","affiliation":[{"name":"Wombat Support &amp; Rescue NSW\/ACT Inc.  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Mounsey","sequence":"additional","affiliation":[{"name":"School of Health, University of the Sunshine Coast  Sippy Downs Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Carver","sequence":"additional","affiliation":[{"name":"School of Natural Sciences, University of Tasmania  Hobart Tasmania Australia"},{"name":"Odum School of Ecology, Center for the Ecology of Infectious Diseases University of Georgia  Athena USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-8-110"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2664.14084"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.944578"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2020.2475"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijppaw.2021.08.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/2955321"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2023.0169"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2664.14298"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-020-04395-6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13095"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1071\/PC21007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.14082"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2664.13619"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7589\/2018-04-101"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2018.01.007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/fee.1481"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10344-005-0080-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12741"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009090"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.12712"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1890\/140241"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2307\/2937171"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2664.12968"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2664.13467"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-020-04347-0"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-022-07460-4"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-022-05452-y"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-020-07012-8"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/mam.12213"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2010.11.002"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/vrc2.109"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-015-4628-3"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2656.13960"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0376892912000240"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-019-3340-z"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1638\/2019-0197"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-023-07945-w"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149749"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-39.1.179"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2023.02.004"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.7589\/2017-12-310"},{"key":"e_1_2_9_43_1","doi-asserted-by":"crossref","unstructured":"Wilkinson V. S.Carver S.Richards C.Naesborg\u2010Nielsen L.Burgess andK.Mounsey.2024.\u201cData From: Adaptive Interventions for Advancing In Situ Wildlife Disease Management.\u201dUniversity of Tasmania Research Data Portal.https:\/\/doi.org\/10.25959\/st1x-rs32.","DOI":"10.1002\/eap.3019"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2664.14327"},{"key":"e_1_2_9_45_1","first-page":"1","article-title":"Fluralaner as a Novel Treatment for Sarcoptic Mange in the Bare\u2010Nosed Wombat (Vombatus ursinus): Safety, Pharmacokinetics, Efficacy and Practicable Use","volume":"14","author":"Wilkinson V.","year":"2021","journal-title":"Parasites & Vectors"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.20506\/rst.21.1.1326"}],"container-title":["Ecological Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/esajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eap.3019","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/esajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eap.3019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T14:05:56Z","timestamp":1725372356000},"score":1,"resource":{"primary":{"URL":"https:\/\/esajournals.onlinelibrary.wiley.com\/doi\/10.1002\/eap.3019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,5]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/eap.3019"],"URL":"https:\/\/doi.org\/10.1002\/eap.3019","archive":["Portico"],"relation":{},"ISSN":["1051-0761","1939-5582"],"issn-type":[{"value":"1051-0761","type":"print"},{"value":"1939-5582","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,5]]},"assertion":[{"value":"2023-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3019"}}