{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:30:45Z","timestamp":1791869445617,"version":"4.3.4"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,3,20]],"date-time":"2003-03-20T00:00:00Z","timestamp":1048118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report observations on the efficacy and tolerability of topiramate in a sample of five patients with severe symptoms of bulimia nervosa and comorbid mood and\/or anxiety disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Topiramate was added to other psychotropic medication under open\u2010label conditions up to the maximum tolerated dose or until remission of the eating disorder was achieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Topiramate almost completely eliminated binging and purging behavior in three of the five patients. Improvement was maintained throughout the period of follow\u2010up for up to 18 months. One patient showed a partial, temporary response, and the fifth was intolerant of the drug and unable to complete an adequate trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These results suggest strongly that the efficacy of topiramate in patients with bulimia nervosa with and without comorbid mood and anxiety disorders should be investigated more fully. \u00a9 2003 by Wiley Periodicals, Inc. Int J Eat Disord 33: 468\u2013472, 2003.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.10154","type":"journal-article","created":{"date-parts":[[2003,3,21]],"date-time":"2003-03-21T11:59:59Z","timestamp":1048247999000},"page":"468-472","source":"Crossref","is-referenced-by-count":27,"title":["Topiramate in the treatment of severe bulimia nervosa with comorbid mood disorders: A case series"],"prefix":"10.1002","volume":"33","author":[{"given":"James G.","family":"Barbee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,3,20]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.6.967-a"},{"issue":"17","key":"e_1_2_1_3_1","first-page":"60","article-title":"Topiramate in posttraumatic stress disorder: preliminary clinical observations","volume":"62","author":"Berlant J.L.","year":"2001","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200106000-00015"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.1999.10111.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v62n0610"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.2.322-a"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v61n0508"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.10154","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.10154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:15:15Z","timestamp":1700266515000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.10154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,20]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["10.1002\/eat.10154"],"URL":"https:\/\/doi.org\/10.1002\/eat.10154","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3,20]]}}}