{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:39:11Z","timestamp":1789540751277,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T00:00:00Z","timestamp":1072742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Selective serotonin reuptake inhibitor (SSRI) medication does not appear to be effective in ill, malnourished anorexia nervosa (AN) patients. However, it may be effective in preventing relapse after weight restoration. The purpose of this study was to determine whether nutritional supplements could potentiate the effects of fluoxetine in underweight AN subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Twenty\u2010six subjects with AN participated in a trial of fluoxetine. In a double\u2010blind, placebo\u2010controlled manner, subjects received either nutritional supplements or a nutritional placebo. The nutritional supplement included tryptophan (the precursor of serotonin), vitamins, minerals, and essential fatty acids believed to influence serotonin pathway function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in weight gain between subjects treated with fluoxetine plus nutritional supplements versus fluoxetine plus a nutritional placebo. Moreover, there were no significant differences between groups on mean changes in anxiety or obsessive and compulsive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The results of this study suggest that supplement strategies are not a substitute for adequate nutrition and are ineffective in increasing the efficacy of fluoxetine in underweight AN subjects. \u00a9 2003 by Wiley Periodicals, Inc. Int J Eat Disord 35: 10\u201315, 2004.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.10235","type":"journal-article","created":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T21:00:54Z","timestamp":1072818054000},"page":"10-15","source":"Crossref","is-referenced-by-count":76,"title":["Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosa"],"prefix":"10.1002","volume":"35","author":[{"given":"Nicole C.","family":"Barbarich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire W.","family":"McConaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Halmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Gendall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne R.","family":"Sunday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Gaskill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"La Via","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido K.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine H.","family":"Plotnicov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter H.","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,30]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(85)90019-6"},{"key":"e_1_2_1_3_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700036473"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.4.548"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(89)90062-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(199901)25:1<11::AID-EAT2>3.0.CO;2-U"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.174.4013.1023"},{"key":"e_1_2_1_9_1","first-page":"896","volume-title":"Biological Psychiatry","author":"Frank G.F.","year":"2002"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01172967"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110048007"},{"key":"e_1_2_1_12_1","first-page":"952","article-title":"The effects of dieting and weight loss on neuroendocrine responses to tryptophan, clonidine, and apomorphine in volunteers","volume":"44","author":"Goodwin G.M.","year":"1987","journal-title":"Important implications for neuroendocrine investigations in depression. Archives of General Psychiatry"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(05)70385-3"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01273313"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1984.01790150040007"},{"key":"e_1_2_1_16_1","unstructured":"Kaye W.H. FrankG.K. Meltzer C.C. Price J. Drevets W.C. &Mathis C.(2003).Enhanced pre\u2010 and postsynaptic 5HT1A receptor binding after recovery from anorexia nervosa: Relationship to anxiety and harm avoidance. Manuscript submitted for publication."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810300068010"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01013-1"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/ajcn\/47.2.239","article-title":"Glucagon secretion in anorexia nervosa","volume":"47","author":"Kumai M.","year":"1988","journal-title":"American Journal of Clinical Nutrition"},{"key":"e_1_2_1_20_1","first-page":"47","article-title":"Zinc, appetite regulation and eating disorders","volume":"380","author":"McClain C.","year":"1993","journal-title":"Progress in Clinical and Biological Research"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199204)11:3<235::AID-EAT2260110306>3.0.CO;2-T"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/ajcn\/50.5.940","article-title":"Vitamin and trace element status of women with disordered eating","volume":"50","author":"Mira M.","year":"1989","journal-title":"American Journal of Clinical Nutrition"},{"key":"e_1_2_1_23_1","first-page":"226","article-title":"Directivas para el tratamiento diet\u00e9tica de los pacientes que tienen anorexia nervosa basado en una evaluaci\u00f3n de sus estado nutricional [Guidelines for the dietetic treatment of patients with anorexia nervosa based on an assessment of their nutritional status]","volume":"195","author":"Nunez C.","year":"1995","journal-title":"Revista Clinica Espanola"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4679(199906)55:6<685::AID-JCLP3>3.0.CO;2-Y"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199403)15:2<187::AID-EAT2260150210>3.0.CO;2-F"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199511)18:3<257::AID-EAT2260180307>3.0.CO;2-Q"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00967707"},{"key":"e_1_2_1_28_1","volume-title":"Palo Alto","author":"Spielberger C.D.","year":"1970"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.1999.9.195"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.7.1073"},{"key":"e_1_2_1_31_1","first-page":"161","volume-title":"Textbook of psychopharmacology","author":"Tollefson G.D.","year":"1995"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.10235","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.10235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T15:36:28Z","timestamp":1700235388000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.10235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,30]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1002\/eat.10235"],"URL":"https:\/\/doi.org\/10.1002\/eat.10235","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,30]]}}}