{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:51:04Z","timestamp":1788871864526,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,10,16]],"date-time":"2001-10-16T00:00:00Z","timestamp":1003190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["Framework-V Multicenter Research Grant QLK-1999-916"],"award-info":[{"award-number":["Framework-V Multicenter Research Grant QLK-1999-916"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondo de Investigaci\u00f3n Sanitario","award":["00\/258"],"award-info":[{"award-number":["00\/258"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Orlistat (\n                      <jats:italic>tetrahydrolipstatin<\/jats:italic>\n                      ) is an intestinal lipase inhibitor that was approved recently for the management and treatment of obesity. This is the first report of the misuse of orlistat in two normal\u2010weight purging bulimia nervosa (BN) patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method and Results<\/jats:title>\n                    <jats:p>We report two diagnosed cases of BN in two Spanish women who used orlistat as a purging mechanism after binge episodes. In both cases, the onset of the eating disorder was in adolescence. From the beginning, a restrictive diet, binging, and purging behavior (vomiting and using laxatives) were present. Both patients misused this substance as their only purging mechanism after every binge episode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BN patients have used many substances and bizarre behaviors as purging mechanisms. Nevertheless, to the authors' knowledge, these are the first reported cases of orlistat misuse as the only purging mechanism in two BN patients. \u00a9 2001 by John Wiley &amp; Sons, Inc. Int J Eat Disord 30: 458\u2013461, 2001.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.1108","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T15:52:11Z","timestamp":1030290731000},"page":"458-461","source":"Crossref","is-referenced-by-count":24,"title":["Bulimia nervosa and misuse of orlistat: Two case reports"],"prefix":"10.1002","volume":"30","author":[{"given":"Fernando","family":"Fern\u00e1ndez\u2010Aranda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Amor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Jim\u00e9nez\u2010Murcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gim\u00e9nez\u2010Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Tur\u00f3n\u2010Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Vallejo\u2010Ruiloba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,10,16]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_1_3_1","volume-title":"Eating disorders and obesity","author":"Brownell K.D.","year":"1995"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(97)71485-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.3.235"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(97)00006-X"},{"key":"e_1_2_1_7_1","first-page":"241","article-title":"Lipase inhibition: A novel concept in the treatment of obesity","volume":"17","author":"Drent M.L.","year":"1993","journal-title":"International Journal of Obesity"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10640260008251212"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.3.435b"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(199703)21:2<201::AID-EAT12>3.0.CO;2-4"},{"key":"e_1_2_1_11_1","volume-title":"Endorphins, eating disorders and other addictive behaviours","author":"Huebner H.F.","year":"1993"},{"key":"e_1_2_1_12_1","first-page":"614","article-title":"Gewichtsreduktion bei Bulimia nervosa durch missbrauchliche Einnahme von Schilddrusenhormonen [Weight reduction in bulimia nervosa by abuse of thyroid hormones]","volume":"67","author":"Komhuber J.","year":"1996","journal-title":"Nervenarzt"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-5472(97)00019-6"},{"key":"e_1_2_1_14_1","first-page":"201","article-title":"Osteoporotic fractures revealing anorexia nervosa in five females","volume":"63","author":"Maugars Y.","year":"1996","journal-title":"Revue du Rhumatisme (English ed.)"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1991.tb16387.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11509-4"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00384-3"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/07399339209516013"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.1108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.1108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T10:14:19Z","timestamp":1700388859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.1108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10,16]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1002\/eat.1108"],"URL":"https:\/\/doi.org\/10.1002\/eat.1108","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10,16]]}}}