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Fluoxetine (60 mg\/day) decreases the core symptoms of binge eating and purging and associated psychological features in the short term. Cognitive behavioral therapy reduces core behavioral and psychological features in the short and long term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Evidence for medication or behavioral treatment for BN is strong, for self\u2010help is weak; for harms related to medication is strong but either weak or nonexistent for other interventions; and evidence for differential outcome by sociodemographic factors is nonexistent. Attention to sample size, standardization of outcome measures, attrition, and reporting of abstinence from target behaviors are required. Longer follow\u2010up intervals, innovative treatments, and attention to sociodemographic factors would enhance the literature. \u00a9 2007 by Wiley Periodicals, Inc. 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