{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:12:57Z","timestamp":1773303177382,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,7,23]],"date-time":"2007-07-23T00:00:00Z","timestamp":1185148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>Baclofen is a GABA\u2010B agonist that may be useful in the treatment of substance use disorders, and also reduces \u2018binge\u2010like\u2019 eating in rodents. We hypothesized that baclofen might be effective in reducing binge eating episodes in binge eating disorder (BED) and bulimia nervosa (BN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p>Seven women with BED (<jats:italic>n<\/jats:italic> = 4) or BN (<jats:italic>n<\/jats:italic> = 3) took baclofen (60 mg\/day) for 10 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Six out of seven patients completed the full 10\u2010week trial. Five out of seven participants (3 BED; 2 BN) demonstrated 50% or greater reduction of frequency of binge eating from beginning to end of the study. Three out of seven participants (2 BED; 1 BN) were free of binge eating at study end. Four out of seven participants elected to continue baclofen at study end. Baclofen was well tolerated by the participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>In this open\u2010label trial, baclofen was associated with decreased binge eating frequency in patients with BED and BN. \u00a9 2007 by Wiley Periodicals, Inc. Int J Eat Disord 2007<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.20434","type":"journal-article","created":{"date-parts":[[2007,7,23]],"date-time":"2007-07-23T17:46:51Z","timestamp":1185212811000},"page":"687-691","source":"Crossref","is-referenced-by-count":54,"title":["Baclofen for binge eating: An open\u2010label trial"],"prefix":"10.1002","volume":"40","author":[{"given":"Allegra I.","family":"Broft","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia","family":"Spanos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca L.","family":"Corwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurel","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Steinglass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Devlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Attia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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