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The primary outcome was frequency of binge days. Secondary outcomes included frequency of binge episodes, body\u2010mass index (BMI), weight, Clinical Global Impressions Severity (CGI\u2010S), Three Factor Eating Questionnaire (TFEQ), Montgomery\u2013Asberg Depression Rating Scale (MADRS), Hamilton Anxiety Rating Scale (HAM\u2010A), and Sheehan Disability Scale (SDS). Longitudinal random regression analysis was performed for frequency of binge days and episodes, BMI, weight, and CGI\u2010S; analysis of baseline to endpoint change was performed for all outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Sixteen individuals received memantine; 15 completed at least one postbaseline evaluation, 9 completed the study. Mean dose at endpoint was 18.3 mg\/day. Memantine was associated with significant reductions in frequency of binge days and episodes, severity of illness (<jats:italic>p<\/jats:italic> &lt; .001 for both analyses), disinhibition on the TFEQ (<jats:italic>p<\/jats:italic> = .015), and disability on the SDS (<jats:italic>p<\/jats:italic> &lt; .05 for three subscales). There was no significant change in BMI, weight, MADRS, HAM\u2010A, and TFEQ cognitive restraint and hunger.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>In this open\u2010label trial, memantine was well tolerated and effective in reducing binge eating, severity of illness, and disability, but had little effect on BMI and weight. \u00a9 2008 by Wiley Periodicals, Inc. 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