{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:36:22Z","timestamp":1790710582618,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,8,25]],"date-time":"2009-08-25T00:00:00Z","timestamp":1251158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Compelling evidence has suggested a role for serotonin system dysfunction in the pathogenesis of eating disorders (EDs), including anorexia nervosa (AN) and bulimia nervosa (BN). Studies have examined the association between EDs and a functional polymorphism of the serotonin transporter gene promoter (5\u2010HTTLPR). These studies have yielded inconsistent results. The present study aimed to determine conclusively whether there is an association by using a meta\u2010analytic method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Data of over 2,000 participants from eight independent case\u2013controlassociation studies were pooled by using a random effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AN was found to be significantly associated with the S allele (<jats:italic>p<\/jats:italic> &lt; .001) and S carrier (SS + LS) genotype (<jats:italic>p<\/jats:italic> = .007). However, BN was associated neither with the S allele (<jats:italic>p<\/jats:italic> = .49) nor with the S carrier genotype (<jats:italic>p<\/jats:italic> = .33).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These results suggested that the genetic variance of the serotonin transporter gene promoter contributed to the susceptibility of AN. \u00a9 2009 by Wiley Periodicals, Inc. 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